Deck 3 - Central Nervous System Drugs Flashcards
Process by which information is carried across the gap between neuron and postsynaptic cell.
Synaptic Transmission
Conducting an action potential down the axon of the neuron.
Axonal Conduction
It impedes the entry of drugs into the brain and the passages are limited to lipid-soluble agents or via specific transport system.
Blood Brain Barrier
Characterized by falling asleep during normal waking activities, it makes you unable to move and may collapse.
Narcolepsy
State in which abrupt discontinuation of drug use will precipitate a withdrawal syndrome.
Physical Dependence
Decreased response occurring in the course of prolonged drug use.
Tolerance
Slowly progressive neurodegenerative disorder characterized by tremor, rigidity, postural instability and slowed movement.
Parkinson’s Disease
It Improves the patient’s ability to carry out activities of daily life and improves bradykinesia, gait disturbance and postural instability.
Therapeutic Goal
Group of disorders characterized by excessive excitability of neurons in the central nervous system.
Epilepsy
Abnormal motor phenomenon usually associated with seizure and epilepsy.
Convulsions
General term that applies to all types of epileptic events.
Seizure
Most commonly prescribed anticonvulsant drug. Stabilize nerve cells to keep them from getting overexcited by increasing efflux or decreasing influx of sodium ions.
Phenytoin
Effective Against partial seizures and generalized tonic-clonic seizures but not absence seizure. Can be used as daytime sedative “sleeping pills”
Phenobarbital
Cornerstone of epilepsy therapy. Suppresses neuronal discharge by delaying recovery of sodium channels.
Carbamazepine
Bind to a carrier protein and act at a receptor resulting in increased GABA in the brain.
Gabapentin
