DECK 2 AUTONOMIC NERVOUS SYSTEM DRUGS Flashcards
Encourage the neurotransmitter acetylcholine’s activation (imitates parasympathetic)
Cholinergic Drugs action.
Mostly in urine, however some adrenaline can also be found in breast milk.
Catecholemine excreted
Which kind of receptor does acetylcholine bind to in end organs?
Muscarinic
Which receptor is responsible for the peripheral vasoconstriction caused by epi?
alpha-1
Which receptor is involved in the inotropic and chronotropic effects of epi?
beta-1
what is the Terminal Neurotransmitter:of Sympathetic NS
Norepinephrine
Terminal Neurotransmitter: of Parasympathetic NS
Acetylcholine
Drugs that produces a response
Agonist
List the effects of Beta 1 Adrenergic receptors.
Heart - increased heart rate to pump more blood, increased conduction through AV node, increased force of contraction
Kidney - secretes renin to retain water
drugs that block a response
- Effects are determined by the inhibitory action of the drug.
Antagonist
Can you give the SIDE EFFECTS OF ADRENERGIC AGONISTS
Tissue necrosis–check IV sites frequently
Tachycardia, palpitations, tremors, dizziness, increased blood pressure
Urinary retention r/t high doses
Nausea and vomiting –offer food
From supine to standing, an increase in heart rate of at least 20 beats per minute indicates orthostatic hypotension.
ORTHOSTATIC HYPOTENSION
what is the THERAPEUTIC USE of Phentolamine, Phenoxybenzamine
Hypertension
what is the THERAPEUTIC USE of Pindolol
Decrease CO, HR for patients with heart block
what is mnemonic of DUMBBELS
Diarrhea
Urination
Miosis
Muscle Weakness
Bronchorrhea
Bradycardia
Emesis
Lacrimation
S –Salivation/ Sweating