December Flashcards
What are phytochemicals?
molecules in plants that help protect it against its environment, when consumed they have beneficial properties
What effect does MSG have on the body? (in crisps and chinese food)
Stimulates receptors that promote overeating
What are the negative effects of junk food?
- interrupts cellular signalling
- depletes nutrients in the body
- impairs cell function
- reduces life expectancy and performance
- addictive - leads to overeating and malnutrition
- causes inflammation
What conditions are linked to high consumption of junk food?
- atopy
- hormonal imbalance (diabetes, PMS)
- osteoporosis, osteoarthritis, RA
- cardiovascular disease
- migraines, parkinsons, alzheimers
- cancers
Why is grain-fed meat inflammatory?
It has a high omega-6 to omega-3 ratio (20:1)
it is high in arachidonic acid
Why is grass-fed and wild meat less inflammatory?
it has an omega-6 to omega-3 ratio of 2:1
It has higher conjugated linoleic acid
What does conjugated linoleic acid do?
regulates heart health, body weight and blood sugar levels
What are the benefits of organic meat?
higher vitamin, mineral and amino acid profile. Does not contain chemicals or xenoestrogens
What are the benefits of red meat?
complete proteins (contains all 9 essential amino acids), polyunsaturated fats, iron, zinc, B vitamins, phosphorus, selenium
What are the negatives of eating red meat?
- high cholesterol and saturated fats
- more energy to be digested
- pro-inflammatory
- high acidity (due to high sulphur content - turns to sulphuric acid)
What are the benefits of poultry?
- complete protein
- vitamin B1,2,3,5,6,12, E, zinc, iron, magnesium. less saturated fat than red meat
- easier to digest
What are the negatives of eating poultry?
- food poisoning risk
- often intensively farmed
What are the benefits of eggs?
- complete protein, rich sources of selenium, vit A, D, B6, B12, zinc, iron and copper
- good for brain health (choline)
- immunity (vit A, B12, selenium)
- pregnancy (folate and choline)
- Eye health (vit A, antioxidants)
- CV health (raise HDL, choline breaks down homocysteine)
What are the negatives of eating eggs?
- High in arachidonic acid so can be pro-inflammatory
- can be constipating
What are the benefits of eating fish?
- complete protein
- high omega 3
- vitamin D, B2, calcium, phosphorus, iron, zinc, iodine, magnesium, potassium
What are the oily fish?
SMASH - sardines, mackerel, anchovies, salmon, herring
What are the negatives of eating fish?
Mercury, polychorinated biphenyls and dioxins are present in larger, long-living fish
What are the negatives of farmed fish?
- contains dyes, chemicals (Abx, mercury, PCBs)
- lower omega 3 content
- fish are vaccinated and de-sexed
- more diseases in the fish
What are the negatives of canned fish?
- it reduces the vitamin C content of the fish
What are the benefits of eating shellfish/crustaceans?
- complete protein, omega-3, vitamin B12, zinc, iron, magnesium
What are the negatives of eating shellfish/crustaceans?
- high in cholesterol
- food poisoning is common
- often intensively farmed
- accumulate mercury
What are the benefits of organic plants?
- they contain a higher amount of phytonutrients (protecting themselves)
Why are plants good for the microbiome?
- they are prebiotic and probiotic
- they contain lots of fibre
- bacterial digestion of plants produces SCFA which support the intestinal barrier
What is beta-carotene?
an orange pigment, abundant in plants and fruits that functions as an anti-oxidant and a precursor to vitamin A
What are flavinoids?
A diverse group of phytonutrients that are found in almost all fruits and vegetables, they are responsible for the colours
What is lutein?
A types of carotenoid antioxidant that is important in eye and skin health. abundant in leady greens
What is quercetin?
A plant pigment (flavinoid), found in red fruits and vegetables. Anti-inflammatory and anti-histamine properties
What is indole-3-carbinol?
I3C - found in cruciferous veg, helps support healthy oestrogen metabolism
What are glucosinolates?
Sulphur-containing compounds found in cruciferous vegetables
What is lycopene?
A pigment which gives some vegetables and fruit their red colour. It is in tomatoes and has some anti-cancer properties
What are anthocyanins?
A type of flavonoid that gives things purple, red and blue colours, with anti-oxidant properties
What is mucilage?
A thick polysaccharide that is extracted from a plant
What are benefits of eating root veg?
High levels of antioxidants, vits A, B< C and iron - most nutrients in the skin
What are the benefits of beetroot?
Can improve blood circulation and exercise performance by increasing nitric oxide levels (- vasodilation), which can reduce BP
What nutrients are found in potatoes?
vitamin B2, B3, B5, B6, folate, C, iron, magnesium, potassium, beta carotene, lutein, quercetin
What are the benefits of eating potatoes?
- B6 vits and minerals
- high fibre
- promotes vasodilation
What nutrients are in sweet potatoes?
vitamin A, B1, B2, B3, B5. B6, C, calcium, iron, magnesium, potassium, beta-carotene (higher than white potatoes)
What are the benefits of sweet potatoes?
- blood-sugar regulation (high fibre)
- vision
- skin integrity, immunity (vit A)
- brain health (antioxidants)
What are the benefits of eating carrots?
vision, reproductive health, immune, skin and mucus barriers (vit A), Cv health (antioxidants)
What are the benefits of parsnips?
high fibre (digestive health), eye, bone, tissue health (manganese), heart (magnesium, potassium)
What is manganese good for?
Manganese - creaky knees
bone and tissue health
What vegetables are cruciferous (brassicas)?
kale, cauliflower, broccoli, cabbage, brussel sprouts, rocket, bok choy, radish, turnips, mustard greens
What are the benefits of cruciferous veg?
- rich in vitamin Bs, C, E, calcou, iron, potassium, fibre, flavinoids, I3C, sulphur
- glucosinolates
(anti-inflammatory, support liver detoxification, DNA repair, anti-viral and bacterial)
Why do you have to eat vitamin C regularly?
it is water soluble so is excreted regularly
What vitamin is used to make collagen?
C
Why is cabbage good for the gut barrier?
high in L-glutamine - deceases intestinal permeability
How much heating kills off the glucosinolates in cruciferous veg?
heat > 140 degrees for more than a few mins
Should you stop eating brassicas with hypothyroidism?
- no unless you are deficient in iodine
- Just don’t eat lots of raw brassica veg
Why are dark leafy greens good?
- highest percentage of minerals per calorie
- high in chlorophyll (magnesium)
- high in carotenoids and calcium
What are the benefits of kale?
high in iron (anaemia), bone health (calcium), eye and skin (vit A and zinc), CV health (high antioxidants, regulates LDLs), high proteins, B vits
What are the benefits of tomatoes?
- lycopene (decreases cell damage) - higher in cooked or pureed tomatoes
- CV health - antioxidants and lycopene lowers cholesterol
- anti-inflammatory (modulates COX expression)
- anti-cancer (antioxidants)
What are the benefits of allium vegetables?
Abundant in vitamins and minerals
sulphur compounds (antimicrobial and antiviral)
support microbiome (prebiotics)
High in antioxidant and anti-inflammatory flavonoids
Why are leeks good for people with high cholesterol?
The high flavonoid content lowers LDL through inhibiting HMG-CoA enzyme
What are the benefits of celery?
CV health - butlyphthalide lowers cholesterol and BP
reduces joint inflammation (vit C and flavonoids)
skin health (vit A and C)
digestion (increases stomach acid, and high fibre)
What is pectin - and what is it good for?
It is a soluble fibre that binds to fatty substances in the GI tract (inc cholesterol and toxins) and removes them
Why are citrus fruits good for you?
- Antioxidants
- high vits and minerals
- calcium D glutarate (promotes phase 2 reactions) liver detoxification
What are the dirty dozen (high pesticides)?
strawberries, cucumber, celery, pepper, tomatoes, spinach, apple, grapes, chilli, peach, nectarines, potato, kale, courgette
What are the clean fifteen (low pesticides)?
sweet potatoes, papaya, pineapple, peas, melon, sweetcorn, aubergine, grapefruit, kiwi, onions, mushrooms asparagus, avocado, cabbage, mango
What are pulses?
The edible, dry seeds of legumes
What part of legumes causes GI discomfort?
lectins - can add fennel seeds which reduces effect
What are the benefits of legumes?
- high fibre
- immune (zinc, selenium)
- blood (iron)
- CV health (fibre, magnesium, b vits)
- nervous system (b vits and magnesium)
What are the benefits of nuts?
- good source of proteins, healthy fats, vits and minerals
- anti-coagulant (vit E)
- vasodilation - Arginine
- blood sugar regulation
How can you improve the digestibility of nuts?
soak, grind or sprout them
Which nuts can be used to improve thyroid function?
Brazil nuts - 3 a day helps with conversion of T3-T4 (selenium)
Which nut is the best for brain health?
Walnuts - phospholipids and omega-3s that help with memory
How do you improve the fibre content of seeds?
crush them or soak them
Which seeds are highest in omega-3s?
Chia seeds
Which seeds are anti-paracytic?
pumpkin seeds
What seeds should you eat at each part of the menstrual cycle?
first half: 1tbsp flaxseeds and 1 tbsp pumpkin seeds
second half: 1 tbsp sesame and 1 tbsp sunflower
Which seeds contain phytoestrogens?
Flaxseeds
When should culinary herbs be used cautiously?
In pregnancy, breastfeeding, acid reflux and stomach ulcers
what can aniseed be used for?
weak digestion, gas, bloating, IBS, cough, asthma
What can basil be used for?
weak digestion, gas, bloating IBS, cough, colds, anxiety, low mood, fatigue
What can black pepper be used for?
weak digestion, poor circulation, rhinitis, productive cough, viruses
What can cardamom be used for?
weak digestion, indigestion, nausea, bloating, IBS, low mood, coughs, gum disease
What can chilli (capsicum) be used for?
poor circulation, fatigue, IDH
What can cinnamon be used for?
weak digestion, blood sugar regulation, nausea, poor circulation, H.pylori, candidida,
What can cloves be used for?
indigestion, gas, bloating, parasites, tooth pain
What can coriander be used for?
gas, bloating, IBS, fungal infections, chelation of heavy metals, anti-parasitics
What can cumin be used for?
weak digestion, indigestion, gas, bloating, IBS, diarrhoea
What can fennel be used for?
gas, bloating, GIT spasms, cough, low breast milk production
What can fenugreek be used for?
gastritis, constipation, insulin resistance, low milk production
What can garlic be used for?
high cholesterol, hypertension, atherosclerosis, fungal and bacterial infections, parasites
What can ginger be used for?
weak digestion (prokinetic), nausea, poor circulation, inflammation, amenorrhea
What can horseradish be used for?
poor circulation, weak digestion, sinus congestion, worms
What can oregano be used for?
indigestion, gas, bloating, IBS, parasites, bacterial and fungal infections (can rub on the skin)
What can parsley be used for?
gas, bloating, IBS, fluid retention, hypertension, arthritis, amenorrhoea
What can peppermint be used for?
nausea, vomiting, colic, indigestion, flatulence, IBS, diarrhoea, asthma
What can rosemary be used for?
weak digestion, liver support, memory, concentration, depression, circulation
What can sage be used for?
tonsilitis, indigestion, bloating, gastritis, colds, Alzheimer’s, hot flushes (can be used as a gargle)
What can Thyme be used for?
sore throats, cough, asthma, weak digestion, fungal and bacterial infections, parasites, viruses
What can turmeric be used for?
Liver support, high cholesterol, inflammation, low immunity, cancer prevention, Alzheimer’s
What is a rhizome?
The extension of a root (like ginger or turmeric root)
Which doctor came up with the theory of food combining?
Dr Hay
What are the three categories of the Hay diet?
Proteins, starches, neutral foods (fats, veg)
What does the Hay diet principle say about consuming fruit?
It should be consumed away from meals
What is the carb:protein:fat ratio of legumes?
70:20:10
What are vitamins?
Carbon-containing compounds that are essential to the body in small amounts for normal growth and function (in general cannot be produced by the body)
- cannot be turned into energy or tissues, but are vital to energy/tissue prodcution
What is the difference between vitamin insufficiency and deficiency?
insufficient: sub-clinical (vague symptoms)
deficient: clinical signs and symptoms of deficiency
What are the three active forms of vitamin A?
Retinol, rentinal, retinoic acid
What are the functions of vitamin A?
retinol: health of the retina
retinal: colour vision
retinoic acid: growth and differentiation of epithelial cells
reproduction, antioxidant, gene expression
What is a pro-vitamin?
A substance that can be converted into the active form of a vitamin
Give an example of pro-vitamin A
Carotene (alpha, beta, gamma) found in orange plants
Where can pre-formed vitamin A come from?
Animal foods: liver, fish, egg yolk, mackerel, salmon
How do you improve the bioavailability of carotenes?
By cooking/gently steaming
What conditions affect carotene conversion?
hyperlipidaemia, liver disorders, diabetes, hypothyroidism
What is the maximum supplemental dose of vitamin A?
3000mcg
How does vitamin A improve vision?
It is needed for making rhodopsin - the protein that is involved in converting light to an electrical signal in the eye
How does vitamin A help with immune function?
- it enhances T cell proliferation and IL2 secretion
- supports skin and mucous membrane barrier
What is the role of vitamin A in gene expression?
- regulates gene expression
- synthesis of glycoproteins that support the development of bones, teeth and skin
What is the function of vitamin A in reproduction?
- it is required for spermatogenesis
and egg development and implantation
What are the signs of vitamin A deficiency?
- vision impairment
- hyperkeratosis
- reduced skin integrity
- poor bone growth/healing
- poor sense of taste/smell
- lowered immunity
What factors affect vitamin A?
- alcoholism - breaks down retinol, can cause toxicity
- poor fat absorption
- zinc deficiency - zinc is needed to make retinol binding protein
What is the reference intake for vitamin A?
600-700mcg
What are the signs of vitamin A toxicity?
- birth defects
- bone fractures
- dry, red, scaling skin
What drugs can vitamin A interact with?
Warfarin (vitamin A decreases vitamin K absorption therefore increasing bleeding risk)
What are the two types of dietary sources of vitamin D?
Plants: D2 (ergocalciferol) - in mushrooms
Animals: D3 (cholecalciferol) - in oily fish, egg yolks
What are the optimum levels of vitamin D in the blood?
75-125nmol/L
What is the RNI for vitamin D per day?
400IU (up to 2000IU is fine) - D3 is more potent and stays in circulation longer
What are the functions of vitamin D?
- calcium and phosphorus homeostasis (bones, absorption, excretion)
- bone density (if used with calcium and K2)
- supports immune function
- regulates mucosal inflammation
- enhances anti-tumour activity of immune cells
- needed for the production of insulin and its sensitivity
What are the signs of vitamin D deficiency?
- rickets and osteomalacia
- osteoporosis
- asthma
- autoimmune conditions, poor immunity
- MSK pain
What are the causes of vitamin D deficiency?
- low sun exposure
- excessive calcium intake
- lack of dietary fats
- low magnesium (co-factor for vit D)
- impaired liver function
- poor intestinal absorption
What are the symptoms of vitamin D toxicity?
hypercalcaemia symptoms: nausea, diarrhoea, vomiting, weakness, hypertension, constipation
What are the two types of vitamin E?
Tocopherols and tocotrienols (alpha-tocopherol is the main one in human nutrition)
What are the functions of vitamin E?
- immunity (increases phagocyte activity and T cells)
- inhibits platelet aggregation
- improves insulin action and oestrogen activity
- helps with scarring and acne
What are the signs of vitamin E deficiency?
- red blood cell destruction
- easy bruising, slow healing
- nerve damage due to oxidation
What are the symptoms of vitamin E toxicity?
Increased bleeding risk.
What are the three types of vitamin K?
K1: phylloquinone (in dark leafy vegetables)
K2: menaquinones (from gut bacteria, active form)
K3: menadione (synthetic)
What is the optimal intake of vitamin K?
300-500mcg
What are the functions of vitamin K?
- it is dependant for clotting factors 10, 9, 7, 2
- Bone mineralisation - osteocalcin required vitamin K for synthesis
What are the signs of vitamin K deficiency?
excessive bleeding, bruising, bone fractures, soft tissue calcification
Why are babies given vitamin K at birth?
To prevent vitamin K bleeding, due to inadequate vit K transfer across the placenta
What is vitamin B1?
Thiamine
What mineral is needed to convert thiamine into it’s active form?
magnesium
What processing methods affect B1?
- milling, chopping, canning, adding sulphites, baking soda, boiling, freezing
Name some key food sources of B1?
yeast, peas, oranges, nuts, pulses, sunflower seeds, whole grains, meat, fish
What are the functions of B1?
- ATP production (needed to make acetyl-coA)
- needed to make neurotransmitters (GABA, acetylcholine)
What impairs absorption of vitamin B1?
alcohol, tea (tannins), coffee, COCP, stress, antacids
What are the symptoms of B1 deficiency?
- depression, irritability, memory loss, muscle weakness, cramps, GI disturbance
- beriberi disease
- Wernicke-Korsakoff syndrome
What is Riboflavin?
Vitamin B2
Which B vitamin turns urine bright yellow?
B2
What foods are high in B2?
yeast, spinach, wild salmon, mushrooms, almonds, quinoa, lentils, organic eggs, meat
What are the functions of B2/riboflavin?
- involved in ATP production
- liver detoxification (glutathione production, phase 1 liver detox)
- Iron metabolism
What factors can affect absorption and bioavailability of B2?
Low bile salts, antacids, alcohol. Copper, Zinc, caffeine, theophylline
What are the signs of low B2?
angular chellitis, red atrophic tongue, scaly dermatitis, fatigue, poor concentration
What is vitamin B3?
Niacin
What amino acid can niacin be made from?
tryptophan
What are the active forms of niacin (B3)?
NAD and NADP
What are food sources of B3?
mushrooms, leafy greens, yeast, sunflower seeds, sardines.
What is a niacin flush?
skin flush and itch due to supplementation, due to vasodilation
What are the functions of B3?
- ATP production (used to make NAD and NADP)
- lowers LDL secretion, vasodilation
- glucose-tolerance factor
What are the symptoms of vitamin B3 deficiency?
Pellagra: diarrhoea, dermatitis (collar rash), dementia, death
What are the toxicity effects of B3?
hypotension, hyperuricaemia, flush, hypothyroidism, hepatotoxicity
What is vitamin B5?
Pantothenic acid
What are the functions of vitamin B5?
- It is required to make Co-A - needed for ATP production
- fatty acid synthesis
- Used to make GABA and stress hormones
- anti-histamine properties
What foods is B5 found in?
Almost all foods, high in shiitake mushrooms, avocados, nuts and seeds
What can deplete B5 levels?
Alcohol use, stress, recent surgery
What is vitamin B6?
Pyridoxine
What foods is B6 found in?
whole grains, green veg, sunflower seeds, walnuts, bananas, lentils
What are the functions of B6?
- synthesis of GABA, dopamine, noradrenaline, serotonin
- haem production
- lowers homocysteine
- amino acid metabolism
What are the signs and symptoms of B6 deficiency?
skin lesions, dermatitis (fatty acid metabolism issues), mouth ulcer, angular cheilitis, PMS, microcytic anaemia
What are the toxicity effects of B6?
neuropathy, headache, nausea
What food can cause biotin deficiency?
Raw egg white
What foods contain biotin?
liver, egg yolk, whole grains, cauliflower, meat, oily fish
What are the functions of biotin?
- Regulates gene expression (modifies transcription factors)
- supportive of skin, hair and nails
- Improves blood-glucose control
What are the symptoms of low biotin?
dermatitis, dry scaly flaky skin, smooth pale tongue, hair loss and thinning
What is vitamin B9?
Folate (natural form) /folic acid (synthetic form)
What food sources contain folate?
leafy greens, legumes, citrus fruits, liver
What affects the bioavailability of folate?
pancreatic enzymes (a methyl group needs to be attached for it to be absorbed), B12 (needed for methyl group removal)
What are the functions of folate?
- methylation of homocysteine levels
- required for RBC synthesis
- required for neural tube development
What are the signs of B9 deficiency?
skin issues, gut issues, megaloblastic anaemia (affects rapidly dividing cells)
What factors cause B9 deficiency?
alcoholism, oral contraceptive pill, diuretic and aspirin use.
Which drug badly interacts with B9?
Methotrexate (+anticonvulsants)
What is vitamin B12?
Cobalamin (molecules with cobalt in the centre)
What are vegan food sources of B12?
Chlorella, Nutritional yeast, nori, kombu sea vegetables, shiitake and lion’s mane mushrooms
How long does B12 storage last in the liver?
3-5 years
What are the functions of B12?
- myelin production
- serotonin and dopamine production
- choline (for brain function)
- Erythropoesis
- homocysteine cycle
- energy production
What is the most common cause of B12 deficiency?
malabsorption due to low intrinsic factor production
What type of anaemia is caused by low B12 levels?
Pernicious (autoimmune attack on parietal cells in the stomach)
what are the signs of B12 deficiency?
- fatigue
- megaloblastic anaemia
- combine subacute degeneration of the spinal cord
What drugs lower B12 levels?
PPIs, COCP, metformin, alcohol, H2 receptor antagonists
What are the functions of vitamin C?
- antioxidant
- recycles vitamin E and glutathione
- helps convert cholesterol to bile
- helps with iron absorption
- supports synthesis of thyroxine and steroid hormones
- used to make collagen
- serotonin
- fatty acid transport for ATP production
What can affects vitamin C absorption?
- high vitamin C levels (same transporter is used to absorb it)
What are the signs of scurvy/
- gums bleeding
- easy bruising
- muscle degeneration
- poor wound healing
Which condition should you not give high vit C?
Haemochromatosis
What is the primary water-soluble antioxidant in the blood?
Vitamin C
Which process is the most damaging for vitamin E?
Boiling
Casimir Funk coined the term:
Vitamines
What is a vitamin cofactor?
an essential vitamin component of an enzyme
What cofactors are required for the synthesis of B3 from tryptophan?
B6, B2, Iron