DB Lecture 30: DNA Repair

Question 1

List the types of DNA damage.

Answer 1

Mismatched base
Modified base
Covalent bonds between bases
Double Strand break

Question 2

What is the source of mismatch base DNA damage?

Answer 2

replication error

Question 3

What is the source of modified base DNA damage?

Answer 3

spontaneous chemical

Question 4

What is the source of covalent bonds between bases DNA damage?

Answer 4

UV light

Question 5

What is the source of double strand break DNA damage?

Answer 5

XR
chemicals
bleomycin

Question 6

What repair systems are in place for mismatched base DNA damage?

Answer 6

1. 3’ exonuclease proofreading (DNA pol epsilon and delta)

2. mismatched repair (MMR; DNA pol delta)

Question 7

What repair systems are in place for modified base DNA damage?

Answer 7

1. base excision repair (BER; DNA pol beta)

2. direct repair (MGMT

Question 8

What repair systems are in place for covalent bonds between bases DNA damage?

Answer 8

1. nucleotide excision repair (NER; DNA pol epsilon or delta)
2. translesion synthesis (DNA pol zeta and eta)

Question 9

What repair systems are in place for double strand breakage

Answer 9

1. Non-homologous end-joining (NHEJ)

2. Homologous recombination