Day 3, 4, & 5

Question 1

Lysosomal storage disease => glycosaminoglycans

Answer 1

Mycopolysaccharidoses

Question 2

Inability to degrade glycogen

Answer 2

Pompe Disease

Question 3

Inability to deliver acid hydrolases into lysosomes

Answer 3

Mucolipidoses I and II (I-cell)

Question 4

Used to prevent protein degradation in multiple myelome

Answer 4

Proteasome inhibitors

Question 5

Disease where certain proteins in the hippocampus and cerebellum are not degraded

Answer 5

Angelman syndrome

Question 6

Defective E3 subunit that produces HIF1a/HIF2a; leads to cancer/tumor

Answer 6

Von Hippel-Lindau syndrome

Question 7

2 major buffer systems in the cell

Answer 7

Phosphate and protein

Question 8

Na/HCO3 cotransporter and Cl-HCO3 exchanger are

Answer 8

Acid loaders

Question 9

Creating acidic intracellular compartments using V-type H+ pumps use

Answer 9

ATP

Question 10

Used in long-term copmensation of cell volume changes

Answer 10

Osmolytes (sorbitol and inositol)

Question 11

Hyperglycemia causes excessive ______ production in diabetes

Answer 11

Sorbitol