Day 1 & 2

Question 1

Formed by mainly alpha helices and hydrophobic amino acids

Answer 1

Transmembrane domains

Question 2

Heat shock protein that prevents premature folding

Answer 2

HSP70

Question 3

Heat shock protein that folds the protein using ATP

Answer 3

HSP60

Question 4

Causes lung and liver problems by aggregating in the ER

Answer 4

alpha1-antitrypsin

Question 5

Protein misfolding that has excessive Beta sheets

Answer 5

Creutzfeld-Jacob or Amyloidosis

Question 6

Serum amyloid A fragments

Answer 6

Rheumatoid arthritis

Question 7

antibody Light chain fragments

Answer 7

Multiple myeloma

Question 8

Beta-amyloid fragments

Answer 8

Alzheimer

Question 9

Oxygen radicals in RBCs; causes heinz bodies

Answer 9

G6P dehydrogenase deficiency

Question 10

Used in assessing LUNG MATURITY of fetus

Answer 10

Choline (Lecithins)

Question 11

Most common polar head in plasmalogens

Answer 11

Ethanolamine

Question 12

Lipid that plays a role in apoptosis signaling; Annexin V assay

Answer 12

Serine

Question 13

Essential in the synthesis of secondary messengers

Answer 13

Inositol

Question 14

Used to assess FETAL LUNG DEVELOPMENT

Answer 14

Glycerol

Question 15

Cholesterol _____ are completely hydrophobic

Answer 15

Esters

Question 16

Causes the indent in RBCs, spherocytosis

Answer 16

Spectrin and Ankyrin

Question 17

Enzyme that transfers electrons

Answer 17

Oxidoreductases(dehydrogenases)

Question 18

Add or remove atoms (without ATP)

Answer 18

Lyases

Question 19

Forms bonds (with ATP)

Answer 19

Ligases

Question 20

Non-protein component of an enzyme that is tightly bound

Answer 20

Prosthetic group

Question 21

Non-protein component of an enzyme that is loosely bound

Answer 21

Coenzyme

Question 22

Forms covalent bond with substrate

Answer 22

Activation-transfer

Question 23

Does not form covalent bond with substrate

Answer 23

Oxidation-reduction

Question 24

Deficiency in thiamine pyrophosphate results in

Answer 24

Beriberi

Question 25

Zinc containing enzyme that oxidizes ethanol

Answer 25

Alcohol dehydrogenase

Question 26

Required for kinases to bind phosphate groups

Answer 26

Magnesium

Question 27

Target of penicillin (transition state inhibitor)

Answer 27

Glycopeptidyl transferase

Question 28

Allopurinol targets (transition state inhibitor)

Answer 28

Xanthine oxidase

Question 29

Organophosphorous covalently binds to

Answer 29

Acetylcholinesterase

Question 30

Metal ion that causes anemia

Answer 30

Aluminum

Question 31

Covalently acetylates active site of COX-1

Answer 31

Aspririn

Question 32

Isoenzyme of glucose metabolism that has higher affinity (RBCs)

Answer 32

Hexokinase

Question 33

Competitive inhibitor of HMG-CoA reductase

Answer 33

Statins

Question 34

Decreases Km, Vmax stays the same

Answer 34

Competitive

Question 35

Decreases Vmax, Km stays the same

Answer 35

Non-competitive

Question 36

Decreases Vmax and Km

Answer 36

Uncompetitive

Question 37

Decreases Vmax, Km unchanged (Long term)

Answer 37

Irreversible

Question 38

Allosteric inhibition is a form of _______ inhibition

Answer 38

noncompetitive

Question 39

Going from taut to relaxed in cooperativity

Answer 39

Increases affinity

Question 40

Lysine and arginine are targets of

Answer 40

ADP-Ribosylation

Question 41

cAMP usually ________ protein kinase A

Answer 41

Phosphorylates