Day 1 Revised

Question 1

Baclofen

Answer 1

CNS muscle relaxant

i - relieve acute/painful/discomfort MSK cdx

ta - MOA unknown, work w/ spinal reflex causes spasticity

ci - rheumatoid dz, assist movement, posture, or fx, preg C/lact

c - cardiac dz, muscle weakness, seizure hx, hep/renal dz

ae - GI/GU, CNS dep, arrhy, hypoT

di - CNS dep, ETOH

ni - taper dose, baseline MSK, combo therapy, inc fiber if constipation, take wi/ food

Question 2

Dantrolene

Answer 2

direct muscle relaxant

i - muscle spasticity of severe/chronic dz (MG, MS, ALS, tetanus), malignant hyperthermia, botox

ta - enter muscle interfere Ca release -> prevent muscle contraction

ci - active hep dz, spasticity assisting movement, posture, or fx, infection at injection site, preg/lact

c - female, >35 yo (fatal hepatotoxicity), hep hx, cardiac dz, resp dep, preg

ae - GI/GU, CNS dep, hepatotoxicity, hepatitis, skin (rash, acne, photosensitive)

di - CNS dep, ETOH, estrogen inc hepatotoxicity risk

ni - report s/s liver dysfx, LFT baseline/monitor, no driving