Darmani- Pharmacodynamics

Question 1

is a tertiary structure on that shares interactions with nearby amino acids?

Answer 1

no. they share interactions with distant amino acids

Question 2

what is the agent that binds to a receptor?

Answer 2

agonist

Question 3

if the allosteric site is bound by an agent and does not have an effect, what kind of agent is bound by the allosteric site?

Answer 3

antagonist

Question 4

in G-Protein receptors, where is the binding domain and where is the phosphorylation site?

Answer 4

binding-> near the N-terminal

phosphorylation-> C-terminal

Question 5

in intracellular receptors in the N-domain still the binding domain?

Answer 5

no the C- domain is.

Question 6

during intracellular receptor binding a steroid is bound and brought into the cell. what carries the steroid to the nucleus? and what happens to the receptor in the nucleus?

Answer 6

chaperone

it dimerizes

Question 7

in the G-protein, what subunit inactivates it?

Answer 7

the alpha subunit inactivates the GDP

Question 8

what cascade do G-proteins activate?

Answer 8

target enzymes-> second messengers-> protein kinases-> effectors

Question 9

what is it called when one GPCR couples to multiple G-proteins?

Answer 9

divergence coupling

Question 10

do GIPs active GTPas activity by inhibiting G-protein function?

Answer 10

no they exert the opposite effects

Question 11

calcium is a known to be a second messenger. what else does it do?

Answer 11

integrates signaling systems

Question 12

what happens if you chronically deprive a receptor of excitation?

Answer 12

the receptors will up regulate and increase density. becoming more supersensitive

Question 13

in homologous desensitization G-P-coupled receptor kinases (GRKs) phosphorylate what? and what happens to desensitzation?

Answer 13

only phosphorylates agonist occupid receptors.
initially minimal desensitization but then there is an increase in receptor affinity by arrestins leading to maximal desensitization