Damage To Host

Question 1

How does cell and tissue damage result directly from bacterial action?

Answer 1

Secretion protein toxins (exotoxins)

Question 2

How do we produce non-toxic immunogenic forms of exotoxins?

Answer 2

Denaturing e.g by heat or acid

Question 3

What are the 2 broad groups of exotoxins?

Answer 3

1) cytolysins

2) intracellular enzymatic toxins

Question 4

What is the function of cytolysins?

Answer 4

Interact with host cell membranes

Question 5

What is the action of enzymatic intracellular toxins?

Answer 5

Poison host cells by specific catalytic activity

Question 6

Another term for enzymatic intracellular toxins?

Answer 6

A-B toxins

Question 7

What type of toxins are tetanus and botunlinum toxins?

Answer 7

Neurotoxins

Question 8

What is the action of superantigen (SAg)?

Answer 8

Bridges weakly interacting MHC class II and TCR by binding outside the normal antigen binding pocket

Question 9

What is the indirect damage caused by bacteria?

Answer 9

Consequences host immune response to pathogen

Question 10

Which bacteria causes the chronic infection leprosy?

Answer 10

Mycobacterium leprae

Question 11

What type of enzymatic toxin is the Shiga toxin?

Answer 11

Glycosidase modifies rRNA

Question 12

Other than mycobacterium tuberculosis, which mycobacterium involves granuloma infection?

Answer 12

Mycobacterium leprae

Question 13

Which bacterium causes syphilis?

Answer 13

Treponema pallidum

Question 14

What type of bacterium is Treponema pallidum?

Answer 14

Spirichaete

Question 15

What is Lyme’s disease?

Answer 15

Tick-borne disease caused by Borrelia burgdorferi

Question 16

What are 2 features Lyme’s disease?

Answer 16

LPS-induced inflammation and type III hypersensitivity