D8 pH and tablet coating Flashcards
1
Q
Why do we coat tablets?
A
protection from environmental factors mask bitter/unpleasant taste ease of swallowing mask batchwise differences in tablet colour identification mechanical strength control when drug released
2
Q
What are the 3 different tablet coating?
A
film coating
sugar coating
compression coating
3
Q
How is film tablet composed?
A
film sprayed onto tablet on a rotated, mixed tablet bead
4
Q
What can be film coated?
A
capsules, pessaries, granules
5
Q
Name 3 cellulose ethers
A
hydroxypropyl methylcellulose (HMPC) hydroxypropyl cellulose (HPC) hydroxyethyl cellulose (HEC)
6
Q
What is CAP?
A
cellulose acetate phthalate - a pH sensitive cellulose derivative
7
Q
What can pass through the pyloric sphincter?
A
small particle not large intact tablets
8
Q
What are MUPS?
A
multiple unit pellet system EC particles compressed into a tablet
9
Q
How do MUPS works?
A
tablet disintegrates in stomach and small ec particles can pass through pyloric sphincter
