D4 Flashcards

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1
Q

Actinic keratosis lesions?

A

Scaly
Papular/plaque
Surrounding skine show sign of solar damage(Telangiectasia and hyperpigmentation)

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2
Q

The common area affected?

A

Face
Scalp
Lateral neck
Dorsal surface of the hand

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3
Q

Progression?

A

May progress to SCC in some patient

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4
Q

managment?

A

Small: Cryotherapy(liquid nitrogen)
Large: Fluorouracil

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5
Q

Indication for biopsy?

A

Size >1 cm
Ulceration
Induration
Failure of drug therapy

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6
Q

Molluscum contagiousum etiology?

A

Poxvirus

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7
Q

Lesion?

A

Papule
Central umbilication
Surrounding pruritis
Involve all body parts except palm and sole

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8
Q

Risk?

A

Skin to skin contact

HIV(discriminate)

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9
Q

Treatment of acne vulgaris?

A

Depend on type

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10
Q

Comedonal acne?

A

Close or open comedones in forehead, nose, and chine

May progress to inflamatory pustule/nodule

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11
Q

Treatment?

A
Topical retinoid
Biologic agent(Salicylic,azelaic or glycolic acide)
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12
Q

Inflammatory acne?

A

Inflamed papule/pustule;erythema

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13
Q

Managment?

A

Mild: Retinoid + Benzoil peroxidase
Moderate: Add topical Ab(clindamycin, erythromycin)
Sever: Add oral antibiotic(Tetracycline)

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14
Q

Nodular(cystic) acne?

A

Nodule
Cyst
May form sare or sinus

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15
Q

Tx?

A

M: Topical retinoid + benzoyl peroxidase + topical ab
S: Add oral antibiotic(Tetracycline)
Unresponsive: oral isotretinoin

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16
Q

cause for acne?

A

hyperkeratinization
Increase sebum production
P.Acne colonization

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17
Q

Indication for oral Ab in acne?

A

Sever inflammatory and nodulocystic acne
Widspread involvment(Back and upper shoulder)
failure of adding topical Ab in Moderate I/ND acne

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18
Q

Treatment of MC?

A

curritage
Cryotherapy
Topical agent(podophylotoxine)

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19
Q

Dermatitis herpetiformis (DH)?

A

rare
chronic, autoimmune skin condition
characterized by the presence of groups of severely itchy blisters and raised red skin lesions.

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20
Q

These are most commonly located on the?

A
elbows
knees
buttocks
lower back 
scalp.
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21
Q

Can you have dermatitis herpetiformis without celiac disease?

A

Dermatitis herpetiformis patients usually don’t have the digestive symptoms that go along with celiac disease.
Almost all patients with dermatitis herpetiformis have celiac disease, though the disease is asymptomatic (they have no gastrointestinal symptoms).

22
Q

Dermatitis herpetiformis is treatement?

A

gluten-free diet and an oral antibiotic called dapsone.. If dapsone doesn’t help, prescribe sulfapyridine or sulfasalazine.

23
Q

Necrobiosis lipoidica diabeticorum (“NLD”) ?

A

is a rash that occurs on the lower legs. It is more common in women, and there are usually several spots. They are slightly raised shiny red-brown patches. The centers are often yellowish and may develop open sores that are slow to heal.

24
Q

Discoid lupus lesions?

A

often red, scaly, and thick.
Usually they do not hurt or itch.
Over time, these lesions can produce scarring and skin discoloration (darkly colored and/or lightly colored areas).

25
Q

Lesions most often appear?

A

on the face, ears, scalp, neck, and hands

26
Q

Herptic witlow?

A

HSV infection of hand

virus enter on skin defect after contact

27
Q

Lesion?

A
Prodrome symptom(fever..)
Grouped Vesicular rash on erythemetous base
Tingling
Pain 
Burning
28
Q

managment?

A

self resolve

acyclovir in immunocompromized

29
Q

Senile/actnenic/solar purpura cause?

A

Loss of elastic fiber in perivasculas spese–rapture of vesseles during skine streching

30
Q

CM?

A

Common in older
Minley affect posterior forarm and hand
Echemosis
Hemosidrosis in skine(Hyperpigmentation/brown discoloration of akin)

31
Q

Insidence and severity common in?

A

Anticoagulation
NSAID
Corticosteroid

32
Q

Macular skin lesion in NF and TS?

A

NF:Cafe-au-lait spote/hyperpigmented)
TS:Ash-leaf spote/Hypopigmented/

33
Q

Lichens panus oral lesion?

A
White papule/plaque 
Lesion conected by white lacy lesion(Wickham stria)
Mucosal athtophy
Ulcer
Erythema
Can present w/o skine involvment
34
Q

Pathophysiology of Lichen planus?

A

CD8 reaxn after triger(Infn,Drug and allergen) exposure

35
Q

Telogen effluvium CM?

A

Acte, diffiuse, non-inflamatory hair loss
Scalp and hair fibers apear normal
Hair shaft easily pulled out(>10-15 % once)
MCC of hair loss in adult

36
Q

Triggers?

A
Sever illness, fever, and surgery
Pregnancy, child birth
Emotional stress
Endocrine and nutritional problem
Wight loss
37
Q

Pathophysiology?

A

Most of follicles pass to rest/sheding phase

38
Q

Normal hair follicle stage?

A
Growth phase(90%)--anagen
Transformation phase(<1%)--catagon
rest/sheding phase(<10%)--telogen
39
Q

managment?

A

Reasurance/self limited/

Tx underlining cause

40
Q

Achantosis nigrican Cxs and ass.disease?

A

Benign: Insulin resistance(DM,PCOS)
Malignant:GU and GI malignancy(rapid onset and can affect unesual are like MM,palm and sole)

41
Q

Caracterstich?

A

Hyperkeratotic and hyperpigmented plaque
It typically affects the armpits, groin and neck.
Valvely texture

42
Q

Addison disease associated skine condition?

A

Generalized hyperpigmentation(area friction(knee,elboe..) and sun light exposure area(and,face,,)

43
Q

Bullous pemphigoid CM?

A
Sever pruritis
Bullea
Erythematous base
Prodrome(Urticarial and eczematous lesion)
Mucosal involvment in some pt
44
Q

Associated disease?

A

Age >65
Malignancy
Nurologic disease(PD,MS…)

45
Q

Pathophisiology?

A

IgG Ab against hemidesmosome

IgG and C3 deposition in DE junction

46
Q

Managment?

A

Topical potent CS(Clobetasole..)–effective

Systemic CS not recomended

47
Q

Biopsy in dermatitis herpitiformis?

A

Microabsces in dermal papilla

IgA deposition in dermis

48
Q

When Tinea corporis lesion confluent they form?

A

Flower petal lesion

49
Q

SCC in situ CM?

A

slow growing
red
scaly patch/plaque

50
Q

Treatment of type 1 drug rxn?

A

discontinu drug

mild: antihistamin
sever: Im GC and Epiniphrine

51
Q

smptome in mild case?

A

Urticaria
Pruritis
Flushing

52
Q

Sever?

A

Anaphylaxis

Angioedema of larynex