Cytoskeleton stuff

Question 1

What do human erythrocytes have and what do they lack?

Answer 1

Have actin cytoskeleton but lack microtubule and intermediate filaments

Question 2

What do cortical cytoskeleton in RBCs bind to?

Answer 2

Actin binding proteins such as spectrin, ankyrin, and protein 4.1

Question 3

What does spectrin deficiency lead to?

Answer 3

Hereditary spherocytosis (spherical RBCs)

Question 4

What is dystrophin involved in?

Answer 4

Muscular dystrophy (Duchene and Becker)

Question 5

What does ARPC1b deficiency do?

Answer 5

Forms defective Arp2/3 actin filaments, leading to platelet abnormalities, cutaneous vasculitis, and eosinophilia

Question 6

In focal adhesins, bundles of actin filaments are anchored to what?

Answer 6

integrin beta subunits, alpha-actin, vinculin, and talin

Question 7

In Hemidesmosomes, a6B4 integrins do what?

Answer 7

interact with basal lamina of ECM via intermediate filaments and plectin

Question 8

What results when IgG antibodies are directed against hemidesmosome?

Answer 8

Bullous pemphigoid

Question 9

What does E-cadherin malfunction do?

Answer 9

Promotes cancer cell metastasis

Question 10

What do autoantibodies to desmogelin 1 or 3 cause?

Answer 10

Pemphigus vulgaris