Adhesion molecules

Question 1

What disorders are mutations in the integrin genes associated with?

Answer 1

epidermolysis bullosa with pyloric atresia (a6B4 integrin mutation)

congenital muscular dystrophy

leukocyte adhesion deficiency (B2 integrin mutation)

Glanzmann’s thrombasthenia (a2bB3 integrin mutation)

Question 2

What can defective L-selections cause?

Answer 2

leukocyte adhesion disorders

Question 3

What are increased serum levels of soluble E-selectins predictive of?

Answer 3

Ischemia

Scleroderma

Kawasaki disease

Atopic dermatitis

Question 4

What are P-selectins involved in?

Answer 4

Integrin mediated phagocytosis

Question 5

Gastric cancer is caused by mutations in which cadherin?

Answer 5

E-cadherin

Question 6

Loss of cadherins can cause what?

Answer 6

Skin blistering diseases such as bullous pemphigoid

Question 7

Impairment in NCAM-PSA function is linked to what?

Answer 7

Neuropsychiatric and neurodegenerative disorders such as schizophrenia, bipolar disorder, depression, anxiety, and Alzheimer’s

Question 8

Deficiency of Ig superfamily if CAMs involved in the associated with selectins during leukocyte rolling could lead to what?

Answer 8

leukocyte adhesion deficiency diseases