Cytoskeleton Flashcards
Intermediate filaments in the nuclei of cells
Lamins (not to be confused with LAMININS)
Intermediate filaments in epithelia and related structures
Keratins
Intermediate filaments in neurons
Neurofilaments
Intermediate filaments in fibroblasts
Vimentins
Intermediate filaments in glia
Glial Fibrillary Acid Proteins (GFAPs)
Intermediate filaments in skeletal, cardiac, and smooth muscle
Desmin
Example of a microtubule associated protein (MAP)
Role
tau
role in microtubule assembly and stability
Filaments are made from more than one subunit
What are the subunits
Microtubules
alpha and beta
Filaments are made from only one subunit type
Actin
alpha, beta, and gamma
Explore the extracellular environment and are important for the guidance of nerve growth cones and angiogenic blood vessels.
Filopodia
Thin sheet-like projections that pull cells through tissues
Lamellopodia
Guide cells through embryonic development
Membrane blebbing
Allow for local degradation of extracellular matrix
Invadopodia
Located behind lamellopodium.
Couples ____ ___ to ______ - mediated contractility and substrate (e.g. ____ or ________) adhesion necessary for cell to move
Lamella,
Actin network to myosin-II mediated contractility and substrate (e.g. ECM or another cell) adhesion necessary for cell to move