Cytoskeleton

Question 1

Cilial Dyskinesia

Answer 1

• Primary
  
  • Autosomally recessive genetic defect of outer dynein arms (ODA)
• Secondary
  
  • Due to inflammation/injury of tissue

Question 2

Anti-Mitotic Alkaloids

Answer 2

• Colchicine
  
  • Binds tubulin and blocks polymerization
  • Stop
• Taxol
  
  • Forces tubulin into stable MT’s
  • Freeze
• Vinblastine
  
  • De-polymerizes formed MT’s
  • Lop off