Cytoplasm pt.2 - pt.4 Flashcards
Cellular process in which substances are brought into the cell
Endocytosis
Type of endocytosis where the material engulfed is a solid particle
Phagocytosis
Type of Endocytosis where the material engulfed is fluid by nature
Pinocytosis
Pinocytosis is also known as?
Cell Drinking
Type of Endocytosis where the material will only be engulfed and enclosed if the material will bind with a receptor
Receptor-Mediated Endocytosis
Help mediate the liberation of the clathrin-coated vesicle from the plasma memberame
Dynamin
Membrane bound organelle associated with the endocytotic pathways
Endosomes
Sorts out and recycles proteins internalized from the endocytotic pathways
Endosomes
Type of Endosome
- Found near the cell membrane
- First to interact with the endocytotic vesicle
Early Endosomes
Type of Endosome
- Found deeper than the early endosome
- receives the vesicles originating from the early endosome
Late Endosomes
Also known as Prelysosome
Late Endosome
Matures into Lysosomes
Late Endosomes
Site for Intracellular Digestion and turnover of cellular components
Lysosomes
Mature form of late endosomes
Lysosomes
What do you call the inner foldings inside the mitochondria
Cristae
The Mitochondria is most abundant where
Cardiac Muscles & Kidney Tubules
Products of the Kreb Cycles
FADH2 & NADH
Aside from ATP Production, what are the other functions of the mitochondria?
- Synthesis of Steroid Hormones
- Beta Oxidation of fatty acids
- Initiator of Apoptosis
- Synthesis of reactive oxygen species
What do you call programmed cell death
Apoptosis
Breaks down excess hydrogen peroxide into H2O and O2
Peroxisomes
What enzymes do peroxisomes contain?
Catalase Enzymes
Peroxisomes are involved in ____________ of very long fatty acid chains
Beta Oxidation
Peroxisomes aid in the synthesis of __________ for the synthesis of myelin sheath
Plasmalogen
Are made of specific sequences of amino acids
Proteins
________ will determine the proper sequence of amino acids to form a certain protein
Genes
DNA (Gene) is copied in the form of mRNA in the nucleus
Transcription
mRNA codes are read in the ribosomes for protein synthesis
Translation
The _______ will be the one to go out of the nucleus to interact with the ribosome in order to form specific proteins
mRNA
Endoplasmic Reticulum that has ribosomes
Rough ER
Endoplasmic Reticulum that functions to produce proteins
Rough ER
Endoplasmic Reticulum that is continuous with the nuclear membrane
Rough ER
Series of interconnected sacs found within the ER
Cisternae / Cisterns
Shape of the Cisterns in the RER
Saccular
Shape of the cisterns in the SER
Tubular
All proteins (except for antibodies) are produced where?
Liver
Identify:
- Are Protein producing cells
- Has abundant RER and SER
Hepatocytes
Endoplasmic Reticulum that are devoid of ribosomes
Smooth ER
Endoplasmic Reticulum that functions in Lipid Synthesis
Smooth ER
Endoplasmic Reticulum that functions in drug & alcohol metabolism
Smooth ER
Endoplasmic Reticulum that functions to sequester calcium in the muscles
Smooth ER
Modifies, stores, and packages proteins synthesized from the RER
Golgi Apparatus
The Cis Face of the Golgi Apparatus faces where?
RER
The Trans Face of the Golgi Apparatus faces where?
Exit for packaged proteins
Which type of Pathway in the Golgi Apparatus:
Proteins are packed into transport vesicles and are constantly released out side the cell with out the need for any stimuli
Constitutive Pathway
Which type of pathway in the Golgi Apparatus?
Proteins are packed into secretory vesicles which are then stored temporarily
Will only be released with the presence of a stimuli
Regulated Pathway
Which type of protein pathway?
RER > Golgi Apparatus > Else where
Anterograde (forward) Pathway
Which type of protein pathway?
RER > Golgi Apparatus > back to RER
Retrograde Pathway
Protein complexes that coats membrane bound transport vesicles
Coatomers
Two types of Coatomers
Coatomer Protein I (COP I)
Coatomer Protein II (COP II)
Type of COP the mediates retrograde pathway
COP I
Type of COP that mediates anterograde pathway
COP II
Small and abundant protein complexes present in the cytoplasm that:
- Degrades denatured and non-functional polypeptides
- Removes proteins no longer needed by the cells
Proteasome
Two non-membranous cylindrical structure composed of microtubules
Centrioles
Centrioles are composed of how many triplets of microtubules?
9
Centrioles are composed of one pair, which are arranged at a ___________ with each other
Right Angle
Centrioles produces __________________ during cell division
Mitotic spindle fibers
Protein polymers that determine the shapes of cells
Cytoskeleton
Plays an important role in the movements of organelles and cytoplasmic vesicles as well as in the movements of entire cells
Cytoskeleton
3 components of the cytoskeleton
- Microfilaments
- Intermediate Filaments
- Microtubules
Subunit of microfilaments
G-actin monomers
Diameter of Microfilaments
5-7nm
Which of the 3 cytoskeleton components is the thinnest/smallest
Microfilaments
Monomeric proteins of Microfilaments
Globular G-actin
Relative stability of Microfilaments
Dynamic
Polarity of Microfilaments
Positive and negative ends
Structure of Microfilaments
Two intertwined filaments of F-actin
Key functions of which cytoskeletal component:
- Contract and move cells
- Change cell shape
- Cytokinesis
- Cytoplasmic Transport and Streaming
Microfilaments
General Locations of which cytoskeletal component:
- Concentrated beneath cell membrane
- Cell extension (microvili)
Microfilaments
Subunits of Intermediate Filaments
Antiparallel tetramers of two rod-like dimers
Diameter of Intermediate Filaments
8-10nm
Monomeric proteins of Intermediate Filaments
Various a-helical rod-like proteins
Polarity of Intermediate Filaments
No apparent polarity
Relative stability of Intermediate Filaments
Stable
General Locations of which cytoskeletal component:
- Arrayed throughout cytoplasm
- Desmosomes
- Inside Nuclear Envelope
Intermediate Filaments
Key functions of which cytoskeletal component:
- Strengthen cell and tissue structure
- Maintain cell shape
- Maintain nuclear shape
Intermediate Filaments
Subunit of Microtubules
Heterodimers of aB-tubulin
Overall structure of Microtubules
Hollow tube with a wall of 13 parallel protofilaments
Diameter of Microtubules
25nm
Thickest or biggest Cytoskeletal component
Microtubules
Monomeric proteins of Microtubules
a and B tubulin
Polarity of Microtubules
Positive and negative ends
Relative stability of Microtubules
- Dynamic (in the cytoplasm)
- Stable (in axonemes)
General locations of which cytoskeletal component:
- Radiating through cytoplasm (from concentration of centrosomes)
- Axonemes
Microtubules
Key functions of which cytoskeletal component:
- Maintain cell’s shape and polarity
- Provide tracks for organelle and chromosome movement
- Moves Cillia and Flagella
Microtubules