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IHL > Cytokines of Adaptive Immunity > Flashcards

Cytokines of Adaptive Immunity Flashcards

1
Q

TGF-beta - fxns

A

essentially counteracts all other cytokines discussed

inhibits proliferation of lymphocytes and leukocytes

stimulates B cell class switching to IgA

stimulates healing (fibroblasts and macrophages, angiogenesis)

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2
Q

principle macrophage activator (classical macrophage activation)

promotes TH1 differentiation (inhibits TH2)

promotes B cell class switching to IgG

inhibits IgE

stimulates antigen processing in APCs

promotes extravasation

A

IFN-gamma - fxns

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3
Q

Ag-stimulated T cells, LPS-activated macrophages and Tregs

inflammatory stimuli

A

TGF-beta is produced by _____ in response to _____

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4
Q

IL-4 is produced by _____ in response to _____?

A

TH2 cells and mast cells

??? origin, but IL-4 from above cells later (positive feedback)

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4
Q

CD4+ T helper cells (TH2)

basophils and eosinophils

also TH1 cells and NK cells in early phase of allergic response

mast cell/eosinophil degranulation

A

IL-13 is produced by _____ in response to _____

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5
Q

stimulates differentiation of CD4+ T cells into TH2 cells (inhibits differentiation of TH1 cells)

stimulates B cell class switching to IgE

mast cell/eosinophil mediated rxns

induces arginase expression in macrophages -> collagen production and fibrosis

A

IL-4 - fxns

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6
Q

IL-2 - fxns

A

mediates growth, survival and differentiation of T cells required for survival of Tregs (constitutive receptor expression)

stimulates NK cell differentiation

stimulates growth and Ab production in B cells

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6
Q

shared effects w/ IL-4

promotes fibrosis (alternative macrophage activation)

induces TGF-beta -> promotes fibrosis

contributes to pathology of chronic asthma

induces mucus production

induces B cell class switching to IgE

induces inflammation -> expression of VCAM-1 on endothelial cells

A

IL-13 - fxns

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7
Q

IL-13 is produced by _____ in response to _____

A

CD4+ T helper cells (TH2)

basophils and eosinophils

also TH1 cells and NK cells in early phase of allergic response

mast cell/eosinophil degranulation

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8
Q

mediates growth, survival and differentiation of T cells required for survival of Tregs (constitutive receptor expression) stimulates NK cell differentiation stimulates growth and antibody production in B cells

A

IL-2 - fxns

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9
Q

diagram cytokine interaxns btw cells of adaptive immunity

A
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10
Q

TH2 cells and mast cells

???

A

IL-4 is produced by _____ in response to _____?

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11
Q

stimulates growth and differentiation of activated eosinophils

stimulates B cells to class switch to IgA (helminths are often located in GI tract in early stage of infxn)

A

IL-5 - fxns

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12
Q

CD4+ T cells

Ags and costimulators

A

IL-2 is produced by _____ in response to _____?

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14
Q

IL-4 - fxns

A

stimulates differentiation of CD4+ T cells into TH2 cells (inhibits differentiation of TH1 cells)

stimulates B cell class switching to IgE

mast cell/eosinophil mediated rxns

induces arginase expression in macrophages -> collagen production and fibrosis

upregulates expression of HLA-II

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15
Q

TH2 cells and activated mast cells

???

A

IL-5 is produced by _____ in response to _____

16
Q

IFN-gamma - fxns

A

principle macrophage activator (classical macrophage activation)

promotes TH1 differentiation (inhibits TH2)

promotes B cell class switching to IgG

inhibits IgE

stimulates antigen processing in APCs

promotes extravasation

17
Q

NK cells, TH1 cells and CD8+ T cells

NK cells: infected cell surface markers, IL-12

T cells: antigen, enhanced by IL-12

A

IFN-gamma is produced by _____ in response to _____

18
Q

IL-5 is produced by _____ in response to _____

A

TH2 cells and activated mast cells

???

19
Q

IL-5 - fxns

A

stimulates growth and differentiation of activated eosinophils

stimulates B cells to class switch to IgA (helminths are often located in GI tract in early stage of infxn)

20
Q

IFN-gamma is produced by _____ in response to _____

A

NK cells, TH1 cells and CD8+ T cells

NK cells: infected cell surface markers, IL-12

T cells: antigen, enhanced by IL-12

21
Q

IL-2 is produced by _____ in response to _____?

A

CD4+ T cells

Ags and costimulators

22
Q

IL-13 - fxns

A

shared effects w/ IL-4

promotes fibrosis (alternative macrophage activation)

induces TGF-beta -> promotes fibrosis

contributes to pathology of chronic asthma

induces mucus production

induces B cell class switching to IgE

induces inflammation -> expression of VCAM-1 on endothelial cells

24
Q

TGF-beta is produced by _____ in response to _____

A

Ag-stimulated T cells, LPS-activated macrophages and Tregs

inflammatory stimuli

25
Q

essentially counteracts all other cytokines discussed

inhibits proliferation of lymphocytes and leukocytes

stimulates B cell class switching to IgA

stimulates healing (fibroblasts and macrophages, angiogenesis)

A

TGF-beta - fxns

IHL (12 decks)

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