Cytokines, Interferons, and T-Helpers COPY

Question 1

What are the 5 Main T-Helpers?

Answer 1

1. TH1
2. TH2
3. TH17
4. T_FH
5. T-Reg

Question 2

CD40Ligand function?

Answer 2

1. Binds on CD40 (often on B-cells)
2. Promotes Class Switch
3. Can Activate Macrophage (working with IFN-Gamma)

Question 3

What’s the main Type 2 interferon?

Answer 3

IFN-Gamma
“Macro Activator”

Question 4

What cytokines does T_FH Produce?

Answer 4

1. IL-21
2. AND ICOS

“Six members in 21 pilots”

Question 5

What cytokine(s) make T_H2?

Answer 5

IL-4

via GATA3

Question 6

What cytokines does T_H17 produce?

Answer 6

1. IL-17
2. IL-22
3. And IL-6

“One after Sweet Sixteen and Big 2-1”

Question 7

What cytokines does T_H2 Produce?

Answer 7

1. IL-4
2. IL-5
3. IL-13

“TH2 is the Even-Odd Creator”

Question 8

Five Inflammo-kines?

Answer 8

1. TNF
2. CXCL8
3. IL-1 (L +)
4. IL-6 (L +)
5. IL-12

Question 9

What cytokines create Treg?

Answer 9

1. TGF-B
2. IL-2

via FoxP3

“TGIF, Peace out work week!”

“Gotta Relax for the 2-day weekend”

Question 10

What’re the two Type 1 interferons?

Answer 10

IFN-a and IFN-B
Made by most cells
Activate NKs

Question 11

What cytokines create T_FH Cells?

Answer 11

1. IL-6

via Bcl6

“Six members in 21 pilots”

Question 12

Cytokine for early B-cell development?

Answer 12

IL-7

“Jackpot for lympho growth”
Works on T AND B Development

Question 13

What cytokines create Th1?

Answer 13

1. IFN-Gamma
2. IL-12

via T-bet

“TH1 is the Auto-Gamma Radiator”

Question 14

T_H2 Main functions?

Answer 14

1. Promote B-cell ab production
2. Pump out IgE
3. Activate Mast Cells

Question 15

T_H1 main functions in immune response?

Answer 15

1. Activate Macrophages
2. Stimulate B-cells to make abs
3. Activate NK cells

Question 16

What does Treg produce?

Answer 16

1. TGF-B
2. IL-10

“TGIF, Peace out work week!”
“Palms out (10 fingers) means stop!”

Question 17

IL-3 Function?

Answer 17

Hematopoiesis; create lots o’ guys.

Question 18

What cytokines does TH1 produce?

Answer 18

-IFN-Gamma

(Also IL-2, IL-3&GM-CSF)
“Th1 is the Auto-Gamma Radiator”

Question 19

IL-12 Function?

Answer 19

Activate NK cells!
(and TH1)

“Dial 12 for the Ninja Killer hot-line!”

Question 20

T_FH Main Functions?

Answer 20

1. B-cell Iso-Switching
2. Ab production

Question 21

Three functions of IL-2?

Answer 21

1. Self-T-Cell Proliferation
2. Augment IG synthesis
3. Activate NK cells!

Question 22

What cytokine(s) make T_H17?

Answer 22

1. TGF-Beta
2. IL-6
3. IL-23

“Thank God it’s Friday, June 23rd”
“Sweet 17 Birthday Cake”

Question 23

T_H17 main functions?

Answer 23

1. (+) Neutrophil
2. (+) Barrier Integrity

Question 24

Five Innate Cytokines?

Answer 24

1. IFN-a
2. IFN-b
3. TNF-a
4. IL-12
5. (Mid-phase) IFN-Gamma

Question 25

Two Adaptive (Late Phase) cytokines?

Answer 25

1. IL-2
2. IFN-Gamma