Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology > Cytokines, Interferons, and T-Helpers > Flashcards

Cytokines, Interferons, and T-Helpers Flashcards

1
Q

What are the 5 Main T-Helpers?

A
  1. TH1
  2. TH2
  3. TH17
  4. TFH
  5. T-Reg
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

CD40Ligand function?

A
  1. Binds on CD40 (often on B-cells)
  2. Promotes Class Switch
  3. Can Activate Macrophage (working with IFN-Gamma)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What’s the main Type 2 interferon?

A

IFN-Gamma
“Macro Activator”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What cytokines does TFH Produce?

A
  1. IL-21
  2. AND ICOS

“Six members in 21 pilots”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What cytokine(s) make TH2?

A

IL-4

via GATA3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What cytokines does TH17 produce?

A
  1. IL-17
  2. IL-22
  3. And IL-6

“One after Sweet Sixteen and Big 2-1”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What cytokines does TH2 Produce?

A
  1. IL-4
  2. IL-5
  3. IL-13

“TH2 is the Even-Odd Creator”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Five Inflammo-kines?

A
  1. TNF
  2. CXCL8
  3. IL-1 (L +)
  4. IL-6 (L +)
  5. IL-12
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What cytokines create Treg?

A
  1. TGF-B
  2. IL-2

via FoxP3

“TGIF, Peace out work week!”

“Gotta Relax for the 2-day weekend”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What’re the two Type 1 interferons?

A

IFN-a and IFN-B
Made by most cells
Activate NKs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What cytokines create TFH Cells?

A
  1. IL-6

via Bcl6

“Six members in 21 pilots”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cytokine for early B-cell development?

A

IL-7

“Jackpot for lympho growth”
Works on T AND B Development

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What cytokines create Th1?

A
  1. IFN-Gamma
  2. IL-12

via T-bet

“TH1 is the Auto-Gamma Radiator”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

TH2 Main functions?

A
  1. Promote B-cell ab production
  2. Pump out IgE
  3. Activate Mast Cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

TH1 main functions in immune response?

A
  1. Activate Macrophages
  2. Stimulate B-cells to make abs
  3. Activate NK cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What does Treg produce?

A
  1. TGF-B
  2. IL-10

“TGIF, Peace out work week!”
“Palms out (10 fingers) means stop!”

17
Q

IL-3 Function?

A

Hematopoiesis; create lots o’ guys.

18
Q

What cytokines does TH1 produce?

A

-IFN-Gamma

(Also IL-2, IL-3&GM-CSF)
“Th1 is the Auto-Gamma Radiator”

19
Q

IL-12 Function?

A

Activate NK cells!
(and TH1)

“Dial 12 for the Ninja Killer hot-line!”

20
Q

TFH Main Functions?

A
  1. B-cell Iso-Switching
  2. Ab production
21
Q

Three functions of IL-2?

A
  1. Self-T-Cell Proliferation
  2. Augment IG synthesis
  3. Activate NK cells!
22
Q

What cytokine(s) make TH17?

A
  1. TGF-Beta
  2. IL-6
  3. IL-23

“Thank God it’s Friday, June 23rd”
“Sweet 17 Birthday Cake”

23
Q

TH17 main functions?

A
  1. (+) Neutrophil
  2. (+) Barrier Integrity
24
Q

Five Innate Cytokines?

A
  1. IFN-a
  2. IFN-b
  3. TNF-a
  4. IL-12
  5. (Mid-phase) IFN-Gamma
25
Q

Two Adaptive (Late Phase) cytokines?

A
  1. IL-2
  2. IFN-Gamma

Immunology (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions