cytokines H10 Flashcards

10: Aanmaak en selectie van B- en T-cellen

1
Q

CCL21

A

stromale cellen in LN:
-> B-cel migratie naar de lymfeknoop

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2
Q

CCL19

A

stromale cellen in LN:
-> B-cel migratie naar de lymfeknoop

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3
Q

CXCL13

A

FDC:
-> B-cel migratie naar follikel

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4
Q

BAFF

A

FDC:
-> uitrijpen immature B-cellen naar mature B-cellen

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5
Q

Lymfotoxine (LT)

A

B-cel:
->onderhoudt FDC

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6
Q

pax5

A

transcriptiefactor.
->zorgt ervoor dat B-cellen B-cel blijven
->Ig herschikking

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7
Q

λ5, VpreB

A

surrogate light chain:
-> stopzetten herschikking zware keten
-> inductie proliferatie

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8
Q

Notch1

A

T-cel precursor:
interactie met DL4 in cortex thymus
-> T-cel specifieke differentiatie (T committed)
-> herschikking TCR genen (β,δ,γ)
-> IL7 receptor expressie door T-cel
-> proliferatie

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9
Q

CD7

A

signaal van T-cel committed

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10
Q

AIRE

A

Negatieve selectie T-cellen: zorgt ervoor dat elke mTEC een paar 100 eiwitten random tot expressie brengt

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11
Q

IL7

A

In leven houden van T-cellen

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