Cytokines Groups

Question 1

Th1 cytokines

Answer 1

IL 2, IFN-y, IL-12, TNF-B

promotes CD8 function/proliferation, promote inflammation, promote class switch IgG to IgG2a, blocks function of Th2/class switch to IgE, inhibits antiparasitic response and cells (Eosinophils and Basophils)

Question 2

Th2 cytokines

Answer 2

IL-4, IL-5, IL-6, IL-10, IL-13

mediate anti-parasitic immunity & allergy, promote class switch to IgE, promote activation and proliferation of anti-parasitic cells (mast cells & Eosinophils), induce mucus secretions/vasodilation/bronchospasm/gastric contraction, inhibits Th1 function & proliferation

Question 3

PRO inflammatory cytokines

Answer 3

IL-2 
INF-y
IL-12
IL-1
TNF-a 
INF-a and INF-b
IL-6
IL-17

Question 4

ANTI inflammatory cytokines

Answer 4

TNF-b
IL-4
IL-5
IL-6
IL-10