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TR - Immunology > Cytokines/Chemokines > Flashcards

Cytokines/Chemokines Flashcards

1
Q

IL-1, IL-6, IL-7

A

Bone Marrow

Role in B-cell development

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2
Q

IFN-aB

A

Pl-DCs and other cells

Antiviral activity

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3
Q

IL-1, TNF-a

A

Macrophages (tissue Mphage)

Expression of E-selectin on endothelial cells

Expression of L-selectin on leukocytes/lymphocytes at sites of inflammation

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4
Q

IL-8

CXCL8

A

Endothelial cells

Neutrophil recruitment

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5
Q

MCP-1

CCL2

A

Endothelial cells

Monocyte recruitment

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6
Q

CCL-19, CCL-21

A

HEV

Homing of T and B cells into LN

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7
Q

CXCL-10

A

Endothelium (at infection)

Homing of T-cells into peripheral tissues

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8
Q

CXCL-12

A

HEV

Homing of B-cells into LN

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9
Q

CXCL-13

A

(In spleen)

Migration of B-cells into white pulp of Spleen and Follicles of LN

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10
Q

IL-1, IL-2, IL-6, IL-7

A

Thymus

Role in T-cell development

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11
Q

IL-1B, IL-18

A

Inflammasome (formed by NOD-like receptors)

Drive Inflammation

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12
Q

IFN-Y

A

Th-cells, NK-cells

Macrophage activation

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13
Q

IL-12

A

Differentiation of Naive T cells –> Effector T-cells

Stimulates InF-Y secretion by NK cells and T-cells

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14
Q

IL-15

A

Proliferation of NK cells

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15
Q

IL-10, TGF-B

A

Control of Inflammation

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16
Q

IL-1B, IL-18

A

Inflammasome (formed by NOD-like receptors)

Drive inflammation

17
Q

IL-6

A

Monocytes, Macrophages

Major inducer of Acute Phase Proteins and Inflammation

18
Q

IL-4

A

Th2 cells, Mast cells

B cell proliferation
Production of IgE, IgG

19
Q

IL-2

A

Ag activated T-cell

T-cell proliferation

20
Q

IL-7

A

Stromal cells

Proliferation of T-progenitor cells in Thymus

21
Q

XCLI (aka Lymphotactin)

A

T-cell and NK cell stem cell recruitment to Thymus for maturation

22
Q

IL-5

A

Th2 cells

Eosinophil Activation
B-cell proliferation
IgA production

TR - Immunology (2 decks)

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