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Immunology > Cytokines and their respective functions > Flashcards

Cytokines and their respective functions Flashcards

1
Q

Most potent macrophage activator

A

IFN-gamma

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2
Q

Cytokines involved in wound healing

A

TGF-beta and IL-10

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3
Q

What induces IgG switching?

A

IFN-gamma (to IgG1 & 3).

IL-4 directs switching to IgG4

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4
Q

Pro-inflammatory cytokines

A

TNF and IL-1

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5
Q

What induces IgE switching?

A

Primarily IL-4

Also IL-5 (mostly through accumulation of eosinophils) and IL-13

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6
Q

What induces IgA switching?

A

IL-5 (weak against helminths) and TGF-beta

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7
Q

Cytokines involved in TH2 development

A

IL-4

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8
Q

TH2 T cell output

A

IL-4, IL-5, IL-13

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9
Q

Cytokines involved in TH17 development

A

IL-1, IL-6, TGF-beta and IL-23 (for stabilization of TH17 phenotype)

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10
Q

TH17 T cell output

A

IL-17, IL-22

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11
Q

Cytokines involved in TH1 development

A

IL-12

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12
Q

TH1 T cell output

A

IFN-gamma (major output), IL-2, TNF(alpha)

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13
Q

Cytokines involved in Treg T cell development

A

TGF-beta

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14
Q

Treg T cell output

A

TGF-beta, IL-10

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15
Q

Cytokine activators of NK cells

A

IL-2, IL-12 and IFN type I (enhances cytolytic capacity)

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16
Q

Activators of TH1 T cells

A

IL-2 (produced for autocrine use)

17
Q

Cytokine produced by virally-infected host cells

A

IFN type I (alpha/beta)

18
Q

Inhibitors of TH1 T cells

A

Everything produced by TH2 cells (IL-4, IL-5, IL-13) and everything produced by Treg cells (IL-10, TGF-beta)

19
Q

What cytokine reduces expression of class II MHC?

A

IL-10

20
Q

What cytokine up regulates expression of class I and II MHC?

A

IFN-gamma

21
Q

Inhibitors of TH2 T cells

A

IFN-gamma

22
Q

Cytokines that boost intestinal barrier

A

IL-17 and IL-22

23
Q

Cytokine that causes synthesis and release of acute phase proteins

A

IL-6

24
Q

Cytokines that induce neutrophilia

A

IL-1, TNF

25
Q

Cytokines that cause fever

A

IL-1, TNF

26
Q

Best recruiter of neutrophils

A

IL-8

Immunology (18 decks)

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