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Immunity and Inflammation > Cytokines and Complements > Flashcards

Cytokines and Complements Flashcards

1
Q

C3a

A

Attract neutrophils, inc vascular permeability, histamine release

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2
Q

Histamine

A

SMC contraction = increased endothelial permeability

Vasodilation

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3
Q

Prostaglandins

A 
Vasodilation 
Pain 
Endogenous pyogen --> fever 
Vasodilation of afferent arteriole of nephron --> increases GFR
Inhibition of gastric acid secretion
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4
Q

Bradykinin

A

Pain

Vasoactive

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5
Q

TNF alpha

A 
Cytoskeleton effects = increased endothelial permeability 
Endogenous pyogen --> fever
Leukocytosis
Fibrosis
Monocyte (PMN) and SMC migration to intima in atheroma 
Lipoprotien metabolism 
Activates macrophages 
B and T cell proliferation
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6
Q

Leukotrines

A

SMC contraction –> increased endothelial permeability
Activation of leukocytes and macrophages
Vasoactive peptides

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7
Q

IL-1

A 
Change in cytoskeleton --> increased endothelial permeability 
Endogenous pyogen --> fever 
Leukocytosis (activate lymphocytes)
Fibrosis 
Stimulate macrophages 
Acute Phase Response
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8
Q

C5a

A

Margination and emigration of neutrophils

Mast cells, polymorphs and SMC immune response

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9
Q

LTB4

A

Margination and emigration of neutrophils

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10
Q

Bacterial Peptides

A

Margination and emigration of neutrophils

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11
Q

Epithelial growth factor

A

Mitogenic for epithelial cells, hepatocytes and fibroblasts

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12
Q

Vascular endothelial growth factor

A

Angiogenesis (new vessels from existing)

Vasculogenesis (new vessels)

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13
Q

Platelet derived growth factor

A

Migration and proliferation of SMC, fibroblasts and monocytes

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14
Q

TGF beta

A

Fibrosis/ induce fibroblasts

Transforming growth factor

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15
Q

Acute Phase Proteins

A

Produced by the liver and contribute to inflammation, immune recognition and some act as Pattern Recognition Receptors

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16
Q

IL2

A

Activation and proliferation of T cells

Assisting in activation of B cells

17
Q

IL4

A

Growth factor for B cells and Th2 cells
Inhibits Th1 cells
Stimulates IgG and IgE

18
Q

IL5

A

B cell growth and eosinophil differentiation

19
Q

IL10

A

Inhibits Th1
Inhibits macrophage cytokine productions
Simulates antibody production

20
Q

IL12

A

Activates Th1 and NK cells

21
Q

IFN gamma

A

Activates macrophages

Activates Th1 and inhibits Th2

22
Q

C5-9

A

Membrane attack complexes cause cell lysis

23
Q

C3b

A

Allows attachment and stimulates phagocytic cells
Central complement component
Opsonisation

Immunity and Inflammation (2 decks)

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