Cytokines and Chemokines Flashcards
what are the three ways of action cytokines can communicate with cells
autocrine
paracrine
endocrine
what is the role of interferons
interfere with viral replication
what is the role tumour necrosis factor
cell survival, proliferation, differentiation, and death
what is the role of colony stimulating factors
cause the cells to proliferate and differentiate into a specific kind of blood cell
what are chemokine names based on
amino acid sequence
why do cytokines need to be small molecules
so they can move easily through tissues
how do most cytokines act
in paracrine or autocrine most
mostly secreted
what produces cytokines and when
isolated or small clusters of cells
as part of normal activity and/or in response to triggers
why are cytokines effective even with very low concentrations
high affinity for receptors
what do homodimeric cytokine receptor families recognise
erythropoietin and growth hormone
which chains are common chains in heterodimeric cytokine receptor families
beta or gamma
what is the structure of chemokine receptors
7-transmembrane GPCR
