Cells and Structures of the Immune System Flashcards

1
Q

which immune cells are part of the innate immune system

A

macrophages
neutrophils
dendritic cells
natural killer cells

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2
Q

which non-cellular components are part of the innate immune system

A

complement
inflammatory cytokines/chemokines

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3
Q

what are cytokines
what are chemokines

A

cytokines: large and diverse group of pro- or anti-inflammatory factors that regulate the cells of the immune system
chemokines: a group of secreted proteins within the cytokine family whose generic function is to induce cell migration

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4
Q

which immune cells are part of the adaptive immune system

A

T helper cells
cytotoxic T cells
B cells

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5
Q

which non-cellular components are part of the adaptive immune system

A

inflammatory cytokines
antibodies

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6
Q

what is haematopoiesis

A

formation and development of white blood cells and red blood cells from stem cells

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7
Q

which immune cells come from myeloid progenitors

A

granulocytes:
mast cells, basophils, eosinophils,
neutrophils
monocytes

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8
Q

which cells are polymorphonucleated cells

A

basophils, eosinophils and neutrophils

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9
Q

which type of progenitor cell produces monocytes

A

myeloid

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10
Q

when/where do monocytes differentiate into specialised cells

A

after they enter target tissues

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11
Q

which cells do lymphoid progenitors differentiate into

A

NK cells
T cells
B cells

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12
Q

what are the primary lymphoid organs
what is their role

A

thymus
bone marrow
where T and B cells mature and development

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13
Q

what are the secondary lymphoid organs
what is their role

A

lymph vessels
lymph nodes
spleen
site of interaction between immunocompetent cells and antigens

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14
Q

how do the cardiovascular and lymphatic system connect

A

liquid that infiltrates into tissue is drained into capillaries and lymphatic capillaries which carries it back to the heart via lymph nodes

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15
Q

why do high endothelial venules allow lymphocytes to cross the blood vessel wall
where do they go once they do

A

they have thick walls
enter the secondary lymphoid organs

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16
Q

what directs migration of lymphocytes through secondary lymphoid organs

A

chemokines

17
Q

where in the lymph node do T cells and B cells migrate to

A

B-cells - follicles at the edge of the cortex
T-cells - paracortical areas

18
Q

explain organised immune surveillance in the 2nd lymphoid organs

A

APCs enter in lymph carrying antigens and meet with lymphocytes
cells who do not meet their antigen remain for half a day and then leave via lymphatic system before re-entering circulation
cells who do are activated

19
Q

what are PAMPs

A

pathogen associated molecular patterns
simple molecules expresses on pathogens but not self cells