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Immunology > Cytokines (All) > Flashcards

Cytokines (All) Flashcards

1
Q

IL-7

Category
Secreted by / On surface of
Acts upon
Function

A

Development

Bone marrow and thymic stroma

B/T progenitors

B and T development

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2
Q

IL-15

Category
Secreted by / On surface of
Acts upon
Function

A

Development

Bone marrow

NK progenitor

NK development

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3
Q

IL-3

Category
Secreted by / On surface of
Acts upon
Function

A

Development

Bone marrow

Myeloid progenitor

Myeloid development

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4
Q

G-CSF

Category
Secreted by / On surface of
Acts upon
Function

A

Development

Bone marrow

Neutrophil progenitor

Neutrophil development

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5
Q

Erythropoietin (EPO)

Category
Secreted by / On surface of
Acts upon
Function

A

Development

Bone marrow

RBC progenitor

RBC development

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6
Q

Mannose binding lectin

Category
Secreted by / On surface of
Acts upon
Function

A

Pathogen Recognition Receptor

Free protein in blood

Dense mannose/ fucose on pathogen

Opsonization, C’ activation

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7
Q

Surfactant protein

Category
Secreted by / On surface of
Acts upon
Function

A

Pathogen Recognition Receptor

Free protein in blood

Pathogen

Opsonization, C’ activation

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8
Q

Macrophage mannose R

Category
Secreted by / On surface of
Acts upon
Function

A

Pathogen Recognition Receptor

Macrophage surface

Dense mannose/ fucose on pathogen

Phagocytosis

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9
Q

Scavenger R

Category
Secreted by / On surface of
Acts upon
Function

A

Pathogen Recognition Receptor

Phagocyte surface

Anionic polymers and acetyled LDL

Phagocytosis

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10
Q

fMLP R

Category
Secreted by / On surface of
Acts upon
Function

A

Pathogen Recognition Receptor

Innate cell surface

fMet-Leu-Phe bacterial peptides

Innate cell secretion of CK

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11
Q

TLR

Category
Secreted by / On surface of
Acts upon
Function

A

Pathogen Recognition Receptor

Surface and endosome

Bacterial / viral common patterns

Secretion of CK & chemokines, increase co-stimulatory molecules

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12
Q

IL-1

Category
Secreted by / On surface of
Acts upon (2)
Function (2)

A

Pro-inflammatory

Macrophages, keratinocytes

(1) Lymphocytes
(2) Liver

(1) Enhances responses
(2) Induces acute phase protein (C-reactive protein and MBL) secretion

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13
Q

IL-6

Category
Secreted by / On surface of
Acts upon (2)
Function (2)

A

Pro-inflammatory

Macrophages, DC

(1) Lymphocytes
(2) Liver

(1) Enhances responses, ↑Ab production
(2) Induces acute phase protein (C-reactive protein and MBL) secretion

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14
Q

IL-8 (CXCL8)

Category
Secreted by / On surface of
Acts upon
Function

A

Pro-inflammatory

Macrophages, DC

Phagocytes

Chemoattractant for neutrophils, activates binding extravasation

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15
Q

IL-12 (inflammatory)

Category
Secreted by / On surface of
Acts upon
Function

A

Pro-inflammatory

Macrophages, DC

Naïve T cells

TH1, pro-inflammatory, CK secretion

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16
Q

TNFα

Category
Secreted by / On surface of
Acts upon
Function

A

Pro-inflammatory

Macrophages, DC

Endothelium

Extravasation changes; systemic can cause sepsis

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17
Q

IFNα/β

Category
Secreted by / On surface of
Acts upon
Function

A

Pro-inflammatory

Infected cell

NK cells

NK secretion of IFNγ, activate NK to kill, ↑MHC I

18
Q

MHC I

Category
Secreted by / On surface of
Acts upon
Function

A

Surface Molecule of APCs

All nucleated cells

CD8 T cells (CTL)

Killing of Ag-expressing infected cell

19
Q

MHC II

Category
Secreted by / On surface of (2)
Acts upon
Function (2)

A

Surface Molecule of APCs

(1) APC: DC, macrophages
(2) B cells

CD4 T cells

(1) T cell CK secretion to activate macrophages to increase phagocytosis
(2) T cell CK secretion to increase Ab secretion

20
Q

B7-1 / B7-2 (aka CD80 / CD86)

Category
Secreted by / On surface of
Acts upon (2)
Function (2)

A

Surface Molecule of APCs

APC

(1) CD28 (on T cells)
(2) CTLA4

(1) Co-stimulation of T cells
(2) Inhibit T cell activation

21
Q

CD3, ζ

Category
Secreted by / On surface of
Function

A

T Cell Accessory Molecule

T cell

Signal transduction of TCR complex

22
Q

CD4 / CD8

Category
Secreted by / On surface of
Acts upon
Function

A

T Cell Accessory Molecule

T cell

MHC II / I on APC

Adhesion and signal transduction

23
Q

CD28

Category
Secreted by / On surface of
Acts upon
Function

A

T Cell Accessory Molecule

T cell

B7-1/ B7-2 on APC

Signal transduction and co-stimulation

24
Q

CTLA-4

Category
Secreted by / On surface of
Acts upon
Function

A

T Cell Accessory Molecule

T cell

B7-1/ B7-2 on APC

Inhibitor of TCR transduction

25
Q

CD40L

Category
Secreted by / On surface of
Acts upon (2)
Function (2)

A

T Cell Accessory Molecule

T cell

(1) CD40 on macrophages
(2) CD40 on B cells

(1) Activate macrophage (along with IFNγ and correct MHC + Ag)
(2) Required for CD4 T dependent activation of B cells (along w/ MHC-Ag-TCR)

26
Q

LFA-1 / VLA-4

Category
Secreted by / On surface of
Acts upon
Function

A

T Cell Accessory Molecule

T cell

ICAM / VCAM on APC / endothelium

Adhesion

27
Q

IL-2

Category
Secreted by / On surface of
Acts upon (3)
Function (3)

A

Adaptive Immune System

CD4 and CD8 T

(1) CD4 & CD8 T cells
(2) B cells
(3) NK cells

(1) T cell growth stimulation
(2) Increase Ab production
(3) NK growth stimulation

28
Q

IL-4

Category
Secreted by / On surface of (2)
Acts upon (2)
Function (2)

A

Adaptive Immune System

(1) APC
(2) CD4 T cells, mast cells

(1) CD4 T cells
(2) B cells

(1) Induces TH2 responses
(2) Ig class switching to IgE

29
Q

IL-5

Category
Secreted by / On surface of (2)
Acts upon (2)
Function (2)

A

Adaptive Immune System

(1) APC
(2) CD4 T cells, mast cells

(1) CD4 T cells
(2) Eosinophils

(1) Induces TH2 responses
(2) Eosinophil activation

30
Q

IL-12 (adaptive immunity)

Category
Secreted by / On surface of
Acts upon (2)
Function (2)

A

Adaptive Immune System

DC

(1) NK cells
(2) CD4 T cells

(1) Activates NK (DC-NK cross talk)
(2) Induces TH1 responses

31
Q

IFNγ

Category
Secreted by / On surface of (3)
Acts upon (3)
Function (3)

A

Adaptive Immune System

(1) NK cells
(2) CD4 TH1 cells
(3) CD8 CTLs

(1) DC
(2) Macrophages; CD8 T cells (CTLs); B cells
(3) Macrophages

(1) Activates DC (DC-NK cross talk), steers DC to activate CD4 to Th1 response
(2) Macrophage activation (also with CD40L to CD40 and correct MHC + Ag); Stimulate CTL activity; Stimulate C’ activating Ab production (class switch to IgG1, IgG3)
(3) Macrophage activation (also with CD40L to CD40 and correct MHC + Ag)

32
Q

IL-17

Category
Secreted by / On surface of
Acts upon
Function

A

Adaptive Immune System

Th17 cells, some innate cells

Innate cells, neutrophils

Extracellular immunity (esp fungal infections), ↑neutrophil activity, bridges adaptive / innate

33
Q

TGFβ

Category
Secreted by / On surface of (2)
Acts upon (2)
Function (2)

A

Adaptive Immune System

(1) CD4 Tregs, many others
(2) CD4 T cells

(1) T cells
(2) B cells

(1) Inhibition of T cell activation, inhibits Th, CTL, NK
(2) IgA class switch

34
Q

IL-10

Category
Secreted by / On surface of
Acts upon
Function

A

Adaptive Immune System

CD4 Treg, many others

T cells

Inhibition of T cell activation, Th, CTL, NK

35
Q

Igα/β (aka CD79a/b)

Category
Secreted by / On surface of
Function

A

B Cell Accessory Molecule

B cells

BCR complex signal transduction

36
Q

CD5

Category
Secreted by / On surface of
Function

A

B Cell Accessory Molecule

B1 cells

Surface marker (B2 cells are CD5-)

37
Q

CD19

Category
Secreted by / On surface of
Function

A

B Cell Accessory Molecule

B cells

Surface markers from pro-B –> plasmablast

38
Q

CD20

Category
Secreted by / On surface of
Function

A

B Cell Accessory Molecule

B cells

Surface marker from pre-B –> plasmablast

39
Q

TLR4

Category
Secreted by / On surface of
Acts upon
Function

A

B Cell Accessory Molecule

B1 cells

Lipopolysaccharide

Polyclonal activation of B1 cells –> shortlived IgM secretion

40
Q

CR2

Category
Secreted by / On surface of
Acts upon
Function

A

B Cell Accessory Molecule

B cells

C3d deposited on pathogen

C’ activation B2 cells (along with BCR association with Ag on pathogen)

41
Q

CD40

Category
Secreted by / On surface of
Acts upon
Function

A

B Cell Accessory Molecule

B cells

CD40L on CD4 T

Required for CD4 dependent activation of B cells (along w/ MHC-Ag-TCR)

Immunology (5 decks)

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