Cytokines

Question 1

Inflammatory cytokines

Answer 1

1, 6, 17, TNF-alpha

Question 2

Anti-inflammatory cytokines

Answer 2

4, 10, 11, 13, TGF-beta

Question 3

Fx of IL-1

Answer 3

Induces fever, induces acute phase protein secretion

inflammatory

Question 4

Fx of IL-2

Answer 4

Stimulates T cells

inflammatory

Question 5

Fx of IL-3

Answer 5

Stimulates bone marrow

inflammatory

Question 6

Fx of IL-4

Answer 6

Stimulates IgE production,
T differentiation into Th2
(anti-inflammatory)

Question 7

Fx of IL-5

Answer 7

Stimulates IgA production, stimulates differentiation of eosinophils

Question 8

Fx of IL-6

Answer 8

Induces acute phase protein reaction, inflammation, differentiation, antibody secretion

T differentiation into Th17

(inflammatory)

Question 9

Fx of IL-8

Answer 9

Recruits neutrophils to clear infx

Question 10

Fx of IL-10

Answer 10

Downregulates Th1 and MHC-II

anti-inflammatory

Question 11

Fx of IL-12

Answer 11

T differentiation into Th1, activates NK cells

inflammatory

Question 12

Fx of IFN-gamma

Answer 12

Proinflammatory, activates macrophages & Th1

Suppresses Th2

Question 13

Fx of TNF-alpha

Answer 13

Inflammatory and immune upregulator

Question 14

Fx of TGF-beta

Answer 14

Controls cell growth, proliferation, differentiation, apoptosis.

Inhibits cytotoxic T cells.

Inhibits secretion of pro-inflammatory cytokines (TNF-alpha, IFN-gamma)

Prevents proliferation of macrophages

Question 15

What are fibroblasts

Answer 15

Sentinel cells
Synthesise extracellular matrix and collagen for wound healing
Mediate inflammation