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Immunology > Cytokines > Flashcards

Cytokines Flashcards

1
Q

What does pleiotropic effect mean?

A

the ability of cytokines to exert multiple actions

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2
Q

Leukotriene B4 (LTB4)

A

Chemoattractant for neutrophils

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3
Q

IL2

A

Work on T-cells, Autocrine effect on Th. “T-cell growth factor”

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4
Q

IL7

A

B-cells

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5
Q

IL1

A

Fever
Increase selectin and integrin amount on endothelial cells
Activate fibrocytes -> fibroblasts

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6
Q

TNFa

A

Fever
Increase selectin and integrin amount endothelial cells
Activate fibrocytes -> fibroblasts

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7
Q

IL8

A

Chemoattractant for neutrophils and macrophages.

Made by: Mast cells, platelets, neutrophils, monocytes, macrophages, eosinophil, basophils, lymphocyte

Upregulation for intergrins?

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8
Q

Transforming Growth factor beta (TGF-b)

A

Inhibit cellular immunity

Activate fibroblasts

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9
Q

IL4

A

B-cell growth factor and class switch to IgE. Formation of Th2

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10
Q

IL5

A

B-cell differentiation to plasma cells. Class switch to IgA.

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11
Q

IL6

A

Fever. Acute phase proteins

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12
Q

IL3

A

Activate haematopic stem cells.

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13
Q

IL12

A

Costimulator for Th -> Th1

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14
Q

Interferon gamma

A

Very potent activator for macrophages (M1) and NKcells.

Class switch to IgG

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15
Q

IL7

A

Made by stromal cells. B-cell maturation

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16
Q

IL10

A

Inhibit the formation of Th1 (downregulator of cellular immunity)

17
Q

Shared char. of cytokines

A

they exert their functions via membrane receptors (high affinity, low number)
their effect is often tansitional (short half life of their mRNA, negative feedback)
Functional redundancy
Antagonistic, additive, synergistic effects

18
Q

Pro inflammatory cytokines / Antiinflammatory cytokines:

A 
Pro inflammatory:
IL-1
TNF 
IFNgamma  
IL-12 
IL-18 
IL17, 
IL33
Antiinflammatory: 
IL-10 
TGF-Beta 
IL-13 
IFN-alpha
IL-35
19
Q

Chemoattractive molecules

A

LTB4
C5a, C3a
IL-8
N-formylmethionyl peptides

20
Q

Which cytokines are known as “B-cell growth factor”?

A

IL-4,5,6

Immunology (12 decks)

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