B and T-cells

Question 1

What cytokines are produced and secreted by Th1

Answer 1

IFNgamma, TNFa and IL2, IL12

Promote cellular immunity

Question 2

What cytokines are produced and secreted by Th2

Answer 2

IL4, IL5, IL13, IL10. (IL6?)

Promote humoral immunity

Question 3

What cytokines are produced and secreted by Th17

Answer 3

IL17, IL26, IL22

Question 4

What cytokines are produced and secreted by Treg

Answer 4

IL10 and TGFb

Question 5

gamma delta T cell does what?

Answer 5

Migrate to mucosal and cutaneous tissues: first line defense. Antigen recognition is NOT MHC-RESTRICTED

Thought to interact with non-protein antigens that are not processed or associated with classical MHC molecules.

1: Eliminates the damaged cell: cytotoxic
2: Influences surrounding cells: helper

Question 6

Function of Treg

Answer 6

Regulatory Tcells (Tregs) do not prevent initial T activation. They:

1: Inhibit sustained response
2: Prevent chronic and potentially damaging responses

In short: Suppress Th1 and Th2 responses

Question 7

What self antigens are seen in thymus?

Answer 7

• ubiquitous cell-associated and circulating proteins

- The AIRE (autoimmune regulator) controls the expression of self peptides by thyme medullary epithelial cells.

Question 8

Hyper-IgM syndrome

Answer 8

Lack of CD40L on Tcells -> no class switch

Question 9

What does B-cells require to class switch their constant heavy chain?

Answer 9

CD40 and cytokines from T helper cells