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Immunology > Cytokines > Flashcards

Cytokines Flashcards

1
Q

What pathway translates the cytokine to affecting genes in the nucleolus?

A

JAK-STAT tyrosine kinase

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2
Q

IL-1

A

Source: monocytes/macrophages/etc.
Function: Pyrogen/acute phase response, induces ILR expression/IL-2 synthesis in T cells, enhances adhesion in leukocytes/endothelial cells

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3
Q

IL-2

A

Source: TH1 (others)
Function: T cell growth factor, activates T cells/NK cells

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4
Q

IL-3

A

Source: T cells (Others)
Function: Stimulates hematopoiesis

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5
Q

IL-4

A

Source: TH2, mast cells (others)
Function: Promotes TH2 developmen, inhibits TH1/17 development, promotes IgE/IgG4 synthesis by B cells

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6
Q

IL-5

A 
Source: TH2/mast cells
Function: Eosinophil development, class switching to IgA in B cells
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7
Q

IL-6

A

Source: T call, macrophages, others
Function: stimulates Acute phase protein/antibody synthesis, low level pyrogen, stimulates differentiation of B cells to plasma cells

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8
Q

IL-7

A

Source: Bone marrow/thymic stromal cells, some T cells
Function: growth factor for pre-T and pre-B cells

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9
Q

IL-8

A

Source: macrophages, fibroblasts, endothelial, others
Functions: Chemokine that attracts neutrophils and naive T cells

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10
Q

IL-10

A

Source: T reg
Function: Inhibits T cells and macrophages, protects against autoimmunity

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11
Q

IL-12

A

Source: activated macrophages, dendritic cells, B cells
Function: Activates Th1 and NK cells

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12
Q

IL-13

A 
Source: Th2 cells
Function: B cell growth factor, class switch to IgE
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13
Q

IL-17 family

A

Source: Th17 cells
Function: Pro-inflammatory, promotes neutrophil migration/differentiation

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14
Q

IFN alpha/beta

A 
Many cell sources
Function: Induced by intracellular pathogens, anti-viral, induces class 1 MHC expression
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15
Q

Interferon gamma

A 
Source:Th1, NK cells
Function: Selects Th1 subset, inhibits Th2 subset, activates macrophages/NK/Tc cells, promotes class 2 MHC expression
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16
Q

Tumor necrosis factor alpa

A

Source: marcophages, mast cells, others
Function: Inflammation, enhances adhesion molecule expression, enhances macrophage phagocytosis/respiratory burst, induces fever/acute phase protein release/septic shock/cachexia

17
Q

TNF beta (lymphotoxin)

A

Source: T cells
Function: Kills infected cells/tumors

18
Q

Transformation growth factor beta

A

Source: Lymphocytes, macrophages, mast cells, platelets
Function: Stimulates IgA production, inhibits cell-mediated immunity, anti-inflammatory, promotes fibroblast growth and wound healing

19
Q

GM-CSF
M-CSF
G-CSF

A

Source: T cells/monocytes
Function: Promotes growth of granulocytes and/or monocytes (go by name)

Immunology (5 decks)

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