Cytokines Flashcards by Alexis Quade | Brainscape

Q

What are the polarizing cytokines for Th1?

A

IL-12, IL-18, IFN-gamma

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Q

What are the polarizing cytokines for Th2?

A

IL-4

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Q

What are the polarizing cytokines for Th17?

A

TGF-beta, IL-1, IL-6, IL-23 (pyrogens + IL-23)

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Q

What are the polarizing cytokines for Tregs?

A

Il-2, TGF-beta

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Q

What are the polarizing cytokines for Tfh?

A

IL-6, IL-21

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Q

What is the TF for Th1?

A

T-bet

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Q

What is the TF for Th2?

A

GATA3

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Q

What is the TF for Th17?

A

RORgT

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Q

What is the TF for Treg?

A

FoxP3

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Q

What is the TF for Tfh?

A

Bcl-6

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Q

What are the major functions of Th1 cells?

A

activate M1 macs, inflammation, cell-mediated immunity

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Q

What are the major functions of Th2 cells?

A

allergic and anti-helminth response

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Q

What are the major functions of Th17 cells?

A

inflammation

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Q

What are the major functions of Treg cells?

A

regulation and suppression of immune and inflammatory responses

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Q

What are the major functions of Tfh cells?

A

B cell proliferation and differentiation in GC

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Q

What cytokines are released by Th1?

A

IFN-gamma, TNF-beta

Q

What cytokines are released by Th2?

A

IL-4, IL-5, IL-13

Q

What cytokines are released by Th17?

A

IL-17, IL-22

Q

What cytokines are released by Treg?

A

IL-10, TGF-beta

Q

What cytokines are released by Tfh?

A

IL-4, IL-21