Antimitotics Flashcards
What classes of drugs work as antimitotics?
vinca alkaloids
epilones
taxanes
What drugs are vinca alkaloids?
Vincristine, Vinblastine, Vinorelbine
What drug is an epilone?
Ixabepilone
What drugs are taxanes?
cabazitaxel, docetaxel, paclitaxel
What is the difference in toxicities between vincristine and vinblastine?
Vincristine - more CNS effect, less BM suppression
Vinblastine - more BM suppression, less CNS effects
MOA for the Vinca Alkaloids
bind to tubulin at forming end of microtubules to terminate spindle assembly
Resistance in Vinca Alkaloids
decreased accumulation via increased P-glycoprotein (MDR), changes in target proteins
**resistance is not absolute across the class of vincas
Tx uses for Vinca Alkaloids
Vincristine - Hodgkin’s, non-Hodgkin’s
Vinblastine - Hodgkin’s, testicular cancer
Toxicity among Vinca Alkaloid Class
BM suppression, N/V, vesicant, neurotoxicity
What sx occur as a result of Vinca Alkaloid neurotoxicity?
loss of deep tendon reflexes within 2-3 weeks (sign of proper dose), paresthesis (sign of too high of dose), also ANS sx
MOA taxanes
bind to tubulin and ENHANCE and STABILIZE spindle assembly
Resistance to taxanes
decreased accumulation via P-glycoprotein expression
How are taxanes metabolized?
CYP450 enzymes in liver - potential for drug interactions
Toxicity for taxanes
BM suppression, peripheral neuropathy, hypersensitivity/allergic rxns
-paclitaxel formulation with albumin shown to have less hypersensitivity
MOA for Ixabepilone (epilone)
binds to tubulin and ENHANCE and STABILIZE spindle assembly
similar to Paclitaxel
