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Immunology > Cytokines > Flashcards

Cytokines Flashcards

0
Q

IL2

Secreted by: TH cells

A

Target/Activity

Antigen Primed TH and CTLs/ Induces proliferation and enhances activity

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1
Q

Interleukin 1/ IL1

Secreted by: Monocytes, macrophages, B cells, dendritic cells, endothelial cells, other

A

Target/Act:

  1. TH cells/ Costimulates activation
  2. B Cells/ promotes maturation and clinal expression
  3. NK Cells/ enhances activity
  4. Endothelial Cells/increases expression of ICAMs
  5. Macro and Neutrophils/ chemo tactically attracts
  6. Hepatocytes/Induces synthesis of Acute Phase Proteins
  7. hypothalamus/ induces fever
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2
Q

IL3

secreted by: TH cells, NK cells

A

Target/Activity

Hematopoietic cells/supports growth and differentiation

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3
Q

IL4

Secreted by TH2 cells

A

Target/ activity
1. Antigen primed B cells/ Costimulates activation

  1. Activated B cells/ stimulates proliferation and differentiation, induces class switch to IgE
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4
Q

IL5

Secreted by: TH cells and mast cells

A 
Target/ Activity
 1. Activated B cells/ Stimulates proliferation and differentiation induces class switch to IgA
  1. Bone Marrow cells/ induces eosinophil differentiation
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5
Q

IL 6

Secreted by: Monocytes, macrophages, TH2 cells, bone marrow strongly cells

A

Target/Activity

  1. Proliferating B cells/promotes terminal differentiation into plasma cells
  2. Plasma cells/ stimulates antibody secretion
  3. Myeloid stem cell/ helps promote differentiation
  4. Hepatocytes/ Induces synthesis of acute phase proteins
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6
Q

IL7

Secreted by: Bone marrow, thymocytes stromal cells

A

Target/Activity

1. Lymphoid Stem cells/ induces differentiation intro progenitor B and T cells

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7
Q

IL8

Secreted by: Macrophages, endothelial cells

A

Target/ Activity

Neutrophils/ chemokine, induces adherence to endothelium and extravasation into tissues

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8
Q

IL 10

Secreted by: TH2 cells, T reg cells

A

Target/ Activity

Macrophages/ suppresses cytokine production by TH1 cells

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9
Q

IL11

Secreted y : Bone marrow stroma

A

Target/ Activity:

Bone Marrow/ Increase platelet count

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10
Q

IL12

Secreted by: Macrophages, B cells

A

Target/ Activity;

  1. Activated CD8 cells/ acts synergistically with IL2 to induce differentiation into CTLs
  2. NK and LAK cells and activated TH1 cells/ Stimulates proliferation
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11
Q

IL 13

Secreted by TH2 cells

A

Target/ Activity:

B cells/ induces isotope switch to IgE

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12
Q

IL17

Secreted by TH17 cells

A

Target: Activity:

Fibroblasts, endothelial cells, macrophages/ Increases inflammation, and

attracts PMNS, induces IL6,1,
TGFbeta, TNFalpha,IL8

And role in autoimmune disease and allergy

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13
Q

Interferon Alpha type one

Secreted by Leukocytes

A

Target/ Activity:

Uninflected cells/Inhibits viral replication

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14
Q

Interferon Beta Type one

Secreted by Fibroblasts

A

Target/Activity:

Uninflected cells/ inhibits viral replication

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15
Q

IL gamma type two

Secreted by TH1, CTLs, NK cells

A

Target/ Qctivity:

  1. Macrophages/ enhances activity
  2. many cell types/ increases expression of MHC I and II
  3. Proliferating B cells/ induces class switch to IgH2a , blocks IL4 induced class switch to IgE and IgG1
  4. TH2 cells/ inhibits proliferation
  5. Phagocytize cells/ mediates effects important in DTH, treatment for CGD
16
Q

Transforming Growth Factor Beta

Secreted by platelets, macrophages, lymphocytes, mast cells

A

Target/ activity

  1. Proliferating B cells/ induces class switch to IgA
17
Q

TNF alpha

Secreted by macrophages, NK cells

A

Target/ Activity

  1. Tumor cells/ cytotoxic effect
  2. Inflammatory cells/ induces cytokine expression, causes cachexia of chronic inflammation
18
Q

TNF beta

Secreted by: TH1 and C

A

Target/ Activity

  1. Tumor cells/ cytotoxic effect
  2. Macrophages and nuetrophils/ enhances phagocytic activity
19
Q

Granulocyte Colony Stimulating Factor ( G-CSF)

Secreted by: Macrophages and TH cells

A

Target/ Activity
Bone marrow granulocyte precursor/ induce proliferation used clinically to counteract neutropenia following ablative chemotherapy

20
Q

Granulocyte macrophage colony stimulating factor GM-CSF

Secreted by Macrophages and TH cells

A

Target/ Activity
Bone marrow granulocyte and macrophage precursor/ induces proliferation used clinically to counteract neutropenia following ablative therapy

Immunology (6 decks)

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