CD Markers

Question 0

CD3

Answer 0

Cellular Expression: T cells, thymocytes

Function: Signal transduction by the TCR

Question 1

CD 2 ( LFA-2)

Answer 1

Cellular Expression- T cells, thymocytes, NK cells

Function- Adhesion molecule

Question 2

CD4

Answer 2

Cellular Expression: TH cells, thymocytes, monocytes and macrophages

Function: Coreceptor for MCH II interaction, receptor for HIV

Question 3

CD8

Answer 3

Cellular Expression: CTLs, some thymocytes

Functions: Coreceptors for MHC Class I restricted T cells

Question 4

CD14 (LPS receptor)

Answer 4

Cellular Expression: monocytes, macrophages, granulocytes

Function: Bind LPS

Question 5

CD16 ( FCC Receptor)

Answer 5

Cellular Expression: NK cells, macrophages, Neutrophils

Function: Opsonization, ADCC

Question 6

CD18

Answer 6

Cellular Expression: Leukocytes

Function: Cell adhesion molecule ( missing in leukocyte adhesion deficiency)

Question 7

CD19

Answer 7

Cellular Expression: B cells

Function: Coreceptor for CD21 for B cell activation ( signal transduction)

Question 8

CD20

Answer 8

Cellular Expression: Most or all B cells

Function: Unknown role in B cell activation

Question 9

CD21( CR2, C3d receptor)

Answer 9

Cellular Expression: Mature B cells

Function: Receptor for complement fragment C3d, forms Coreceptor complex with CD19, EBV receptor

Question 10

CD25

Answer 10

Cellular Expression: Activated TH cells and T reg

function: Alpha chain in IL2 receptor

Question 11

CD28

Answer 11

Cellular Expression: T cells

Function: T cell receptor for costume layout molecule B 7

Question 12

CD34

Answer 12

Cellular Expression: Precursors of hematopoietic cells, endothelial cells in HEV

Function: Cell-cell adhesion, bind to L-selection

Question 13

CD40

Answer 13

Cellular Expression: B cell, macrophages, dendritic cells, endothelial cells

Function: binds CD40L, role in T-cell dependent B cell, macrophage, dendritic cell and endothelial cell activation

Question 14

CD56

Answer 14

Cellular Expression: NK cells

Function: not know

Question 15

CD152 (CTLA-4)

Answer 15

Cellular Expression: Activated T cell

Function: Negative regulation: Competes with CD28 for B7 binding