Cytokines Flashcards
1
Q
IL-1
A
- acute inflammation
- induces fever
from macrophages
2
Q
IL-2
A
- Stimulates growth and differentiation of T cell receptors
From Th1 cells
3
Q
IL-3
A
Stimulates differentiation and proliferation of myeloid progenitor cells
From activated T helper cells
4
Q
IL-4
A
Stimulates proliferation and differentiation of B cells
* IgE
From Th2 cells
5
Q
IL-5
A
Stimulate production of eosinophils
From Th2 cells
6
Q
IL-6
A
- Stimulates differentiation of B cells
- Induces fever
From macrophages and Th2 cells
7
Q
IL-8
A
Neutrophil chemotaxis
From macrophages
8
Q
IL-10
A
Inhibits Th1 cytokine production
Also known as human cytokine synthesis inhibitory factor and is an ‘anti-inflammatory’ cytokine
* Inhibits IFN-y
From Th2 cells
9
Q
IL-12
A
Activates NK cells and stimulates differentiation of naive T cells into Th1 cells
From dendritic cells, macrophages, B cells
10
Q
IL-13
A
mucus production
From Th2 cells
11
Q
TNF-a
A
- Induces fever
- neutrophil chemotaxi
From macrophages
12
Q
IFN-y
A
activates macrophages
From Th1 cells
