Cells of the innate immune system Flashcards
1
Q
Which cells are present in the innate immune system
A
- Neutrophils
- basophils
- mast cells
- eosinophils
- monocytes
- macrophages
- natural killer cells
- dendritic cells
2
Q
What is the role of the neutrophils
A
Primary phagocytic cell in acute inflammation
Granules contain myeloperoxidase and lysozyme
Most common type of white blood cell
Multi-lobed nucleus
3
Q
What is the role of the basophils
A
Releases histamine during allergic response
Granules contain histamine and heparin
Expresses IgE receptors on the cell surface
Bi-lobed nucleus
4
Q
What is the role of the mast cells
A
- Present in tissues and are similar in function to basophils but derived from different cell lines
- Releases histamine during allergic response
- Granules contain histamine and heparin
- Expresses IgE receptors on the cell surface
5
Q
What is the role of eosinophils
A
- Defends against protozoan and helminthic infections
- Bi-lobed nucleus
6
Q
What is the role of monocytes
A
- Diffferentiates into macrophages
- Kidney shaped nucleus
7
Q
What is the role of macrophages
A
- Involved in phagocytosis of cellular debris and pathogens
- Acts as an antigen presenting cell
- Major source of IL-1
8
Q
What is the role of natural killer cells
A
Induce apoptosis in virally infected and tumour cells
9
Q
What is the role of dendritic cells
A
Acts as an antigen presenting cell
