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BLD 434 > Cytokines > Flashcards

Cytokines Flashcards

1
Q

What are the characteristic cytokine(s) of Th1?

A

IL-2 and IFN-gamma
- function is to activate macrophages

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2
Q

What two cytokines induce differentiation of Th1?

A

IL-12 and IFN-gamma

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3
Q

What cytokine induces of Th2?

A

IL-4

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4
Q

What is the defining TF for Th2

A

GATA-3

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5
Q

what is the defining TF for Th1

A

T-bet

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6
Q

What are the characteristic cytokine(s) of Th2?

A

IL-4 and IL-5
activate cellular and antibody response to parasites

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7
Q

What cytokine(s) induce differentiation of Th17?

A

IL-6 and IL-21

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8
Q

what is the defining TF for Th17

A

ROR gamma T

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9
Q

What are the characteristic cytokine(s) of Th17?

A

IL-17 and IL-6
Enhance neutrophil response to extracellular bacteria

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10
Q

What cytokine(s) induce differentiation of Tfh?

A

IL-16, TGF-beta, and IL-23

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11
Q

what is the defining TF for Tfh

A

BcI6

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12
Q

What are the characteristic cytokine(s) of Tfh?

A

IL-21
Active B cell maturation of antibody response

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13
Q

What cytokine(s) induce differentiation of Treg?

A

TGF-beta

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14
Q

what is the defining TF for Treg

A

FOXP3

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15
Q

What are the characteristic cytokine(s) of Treg?

A

TGF-beta and IL-10
Suppress other effector T cells, limits inflammation

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16
Q

Identify the signature cytokines produced/secreted by Tc

A

Cytotoxins: perforin, Granzymes, Granulysin, Serglycin

Cytokines: ING-gamma, LT, IL-2

Kill virus infected cells

17
Q

Identify the signature cytokines (5) produced/secreted by Th1

A
  • IFN-gamma
  • GM-CSF
  • TNF-alpha
  • LT
  • IL-2
    Helps macrophages to suppress intracellular infections
18
Q

Identify the signature cytokines (5) produced/secreted by Th2

A
  • IL-4
  • IL-5
  • IL-10
  • IL-13
  • TGF-beta

help basophils, mast cells, eosinophils and B cells respond to parasite infections

19
Q

Identify the signature cytokines produced/secreted by Th17

A
  • IL-17
  • IL-21
  • IL-22
  • IL-26

Enhance neutrophil response to fungal and extracellular bacterial infections

20
Q

Identify the signature cytokines produced/secreted by Tfh

A
  • IL-21
  • IL-4
  • IFN-gamma

Help B cells become activated, isotype switching and increase antibody affinity

21
Q

Identify the signature cytokines produced/secreted by Treg

A
  • TGF-beta
  • IL-10
  • IL-35

Suppress activities of other effector T cell populations

BLD 434 (3 decks)

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