Cytokines Flashcards
Constitutes a large family of small molecular weight soluble intercellular signaling molecules secreted by cells and bind to specific cell membrane receptors
Usually diffuse over short distances
Cytokines
Cytokines may be pro or anti-inflammatory in nature
TRUE
Main cytokines involved in acute inflammation
Tumor Necrosis Factor (TNF), IL-1, and chemokines
mainly causes leukocyte recruitment and migration (mainly chemotactic)
Tumor Necrosis Factor (TNF), IL-1, and chemokines
will promote exudation of WBC out of the blood vessels
TNF & IL-1
will promote the systemic effect of inflammation to manifest
TNF, IL -1, IL - 6
both acts as chemotactic factors attracting WBC to the site of inflammation
Chemokines and IL-17
Similar to TNF; greater role in
fever
IL-1
Systemic effects (acute phase response)
IL-6
Recruitment of neutrophils and
monocytes
IL-17
Stimulates expression of
endothelial adhesion molecules
TNF
secretion of other cytokines;
systemic effects
TNF
Cytokine In Acute Inflammation
Tumor Necrosis Factor (TNF), IL-1, chemokines IL 6 IL 17
Cytokine In Chronic Inflammation
IL-12
IFN-y
IL-17
is present in both acute and chronic
inflammation where it exerts same action
of attracting WBC
IL-17