Cytokines Flashcards

1
Q

Constitutes a large family of small molecular weight soluble intercellular signaling molecules secreted by cells and bind to specific cell membrane receptors

Usually diffuse over short distances

A

Cytokines

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2
Q

Cytokines may be pro or anti-inflammatory in nature

A

TRUE

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3
Q

Main cytokines involved in acute inflammation

A

Tumor Necrosis Factor (TNF), IL-1, and chemokines

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4
Q

mainly causes leukocyte recruitment and migration (mainly chemotactic)

A

Tumor Necrosis Factor (TNF), IL-1, and chemokines

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5
Q

will promote exudation of WBC out of the blood vessels

A

TNF & IL-1

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6
Q

will promote the systemic effect of inflammation to manifest

A

TNF, IL -1, IL - 6

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7
Q

both acts as chemotactic factors attracting WBC to the site of inflammation

A

Chemokines and IL-17

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8
Q

Similar to TNF; greater role in

fever

A

IL-1

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9
Q
Systemic effects (acute phase
response)
A

IL-6

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10
Q

Recruitment of neutrophils and

monocytes

A

IL-17

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11
Q

Stimulates expression of

endothelial adhesion molecules

A

TNF

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12
Q

secretion of other cytokines;

systemic effects

A

TNF

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13
Q

Cytokine In Acute Inflammation

A
Tumor Necrosis Factor (TNF),
 IL-1, 
chemokines
IL 6 
IL 17
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14
Q

Cytokine In Chronic Inflammation

A

IL-12
IFN-y
IL-17

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15
Q

is present in both acute and chronic
inflammation where it exerts same action
of attracting WBC

A

IL-17

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16
Q

Activation of
macrophages (increased
ability to kill microbes
and tumor cells)

A

IFN-y

17
Q

Recruitment of
neutrophils and
monocytes

A

IL-17

18
Q
The main cytokine in chronic inflammation
is \_\_\_\_ that activates
macrophages to
become
actively
phagocytic
A

IFN- y (interferon gamma)