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Pathology > Cytokine and surface molecules > Flashcards

Cytokine and surface molecules Flashcards

1
Q

CD3

A

T cell co-receptor

present on all T cells

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2
Q

CD4

A

T cell co-receptor; amplifies TCR response present on helper T cells

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3
Q

CD8

A

T cell co-receptor; amplifies TCR response present on cytotoxic T cells

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4
Q

CD16

A

Fc receptor for IgG, activates NK cell for antibody dependent cell mediated cytotoxicity present on NK cells, neutrophils, monocytes and macrophages

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5
Q

CD25

A

alpha chain of IL-2 receptor

transmembrane protein present on regulatory T cells

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6
Q

CD28

A

co-stimulatory signal necessary for T cell activation (binds with CD80/86 on APC)
present on T cells

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7
Q

CTLA-4 (CD152)

A

28inhibitory signal that downregulates immune system, binds with CD80/86, opposite effect as CD
present onT cells

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8
Q

CD80/86 (B7)

A

Provide co-stimulatory signal needed for T cell activation (ligand for both CD28 and CTLA-4) present on activated B cells and monocytes (APCs)

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9
Q

CD95

A

Fas receptor

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10
Q

IL-1

A

acute phase inflammatory response, recruits inflammatory cells, fever. Increase expression of adhesion factors on endothelial cells to enable transmigration. Endocrine mechanism produced by macrophages, monocytes, fibroblasts, dendritic cells. Can be expresssed by B lymphocytes, NK cells, epithelial cells

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11
Q

IL-2

A

T cell growth factor. Autocrine, secreted by T cells

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12
Q

IL-4

A

TH2 pathway

Produce by TH2 cells-positive feedback (initial cell that produces IL-4 is unknown but may be basophil)

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13
Q

IL-5

A

activates eosinophils; increases immunoglobin secretion

Produced by Th2 cells and mast cells

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14
Q

IL-6

A

acute phase inflammatory response

produced by T cells and macrophages, vascular smooth muscle cells

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15
Q

IL-7

A

promotes maturation of B cell progenitors, paracrine mechanism
produced by bone marrow stromal cells

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16
Q

IL-10

A

anti-inflammatory cytokine- downregulates Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. produced primarilly by monocytes and Th2 hymphocytes

17
Q

IL-12

A

TH1 pathway; stimulates producion of IFN-y, TNF-a, and reduces IL-4 effects
produced by dendritic cells, macrophages

18
Q

IL-13

A

promotes IgE production

produced by Th2 cells

19
Q

IL-15

A

activates NK cells; induces proliferation of NK cells

produced by mononuclear phagocytes following viral infection

20
Q

IL-17

A

Recruit neutrophils and eosinophils; delayed type reactions, increases chemokine production
Secreted by TH17 cells

21
Q

IL-23

A

induces TH17 pathway, recruitment of neutrophils

produced by antigen presenting cells

22
Q

IFN-y

A

activates macrophages; induces MHC II expression

produced by NK cells in innate response, Th1 and CD8 cells in acquired immunity

23
Q

TNF

A

acute phase inflammatory response; acts on neutrophils and endothelial cells. Septic shock. Endocrine mechanism
produced by monocytes

24
Q

TGF-B

A

Down-regulates immune response

produced by macrophages, others

25
Q

cys-cys

A

attract monocytes and lymphocytes but not neutrophils

26
Q

Cys-X-Cys

A

activation and chemotaxis of neutrophils

27
Q

CSFs

A

colony stimulating factors- hematopoiesis

Pathology (7 decks)

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