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Antibiotiques + Antibiothérapie > Cytochromes > Flashcards

Cytochromes Flashcards

1
Q

CYP 1A (1 et 2)

A

le + impliqué dans l’activité carcinogénique, forte capacité et faible affinité

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2
Q

inhibiteurs 1A1

A

fluvoxamine
cirpo
metilexine
propafénone

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3
Q

CYP 2A6

A

dextrométhrophane et barbituriques sont des inducteurs

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4
Q

CYP 2C9

A

forte affinité et faible capacité, polymorphisme important et ++ complexe

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5
Q

inhibiteurs 2C9

A

ritanovir, sulfaphenazole, fluconazole, fluvoxamine

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6
Q

subtrats 2C9

A

bloqueurs angiotensine II, antidepresseurs, hypoglycémiants et AINS

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7
Q

CYP 2C19

A

retrouvé dans plusieurs tissus, mais +++ foie. faible capacité, forte affinité

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8
Q

substrats 2C19

A

IPP, antidepressant

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9
Q

inhibiteurs 2C19

A

fluvoxamine

triclopidine

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10
Q

CYP 2D6

A

forte affinité, faible capacité. prévalence PM varie considérablement selon ethnicité

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11
Q

substrats 2D6

A

antidepressants, antipsychotiques, analgésiques et cardio drugs

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12
Q

inhibiteurs 2D6

A

ritanovir, quinidine, fluoxétine, norfluoxétine, paroxétine, bupropion, cimétidine

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13
Q

CYP 2E1

A

presque exclusivement au foie. 5-7%

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14
Q

substrats 2E1

A

anesthésiques

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15
Q

inhibiteurs 2E1

A

alcool (non chronique), isoniazid (premiere dose), disulfuram

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16
Q

CYP 3A4

A

faible affinité, forte capacité

17
Q

inhibiteurs 3A4

A

ketoconazole, itraconazole, ritanovir, indinavir, clarithro, erythro, diltiazem, norfluoxétine, nefadone, cirpo, norfloxacine

Antibiotiques + Antibiothérapie (3 decks)

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