Cytochrome p450 Flashcards
1
Q
What is the cytochrome p450 system?
A
A collection of liver enzymes that make up a key pathway for drug metabolism and can cause interactions if inhibited or induced
2
Q
What are the drugs that induce the cytochrome p450 system?
A
CRAPS Carbamezapine Rifampicin bArbituates Phenytoin St John's wort
3
Q
What drugs inhibit the cytochrome p450 system?
A
Some Certain Silly Compounds Annoyingly Inhibit Enzymes, Grrrrrr Sodiu valproate Ciprafloxacin Sulphonamides Cimetidine Antifungals Isoniazid Grapefruit juice
4
Q
What drugs are cytochrome p450 substrates? (affected by inducers and inhibitors)
A
COWPATS Ciclosporin, Carbamazepine, Citaloprom Oral Contraceptive pill Warfarin Phenytoin Acetylcholinesterase Theophylline Statins, Steroids
