Cytochrome P-450 Flashcards
1
Q
What are cytochromes?
A
redox active proteins containing a heme with a central iron atom at its core
2
Q
What is the structure of cytochrome P-450?
A
has an iron centre
- 1 water molecule is attached
- 4 nitrogen atoms
- 1 cysteine is attached = via a sulphur
3
Q
What are the negative side effects of cytochrome P-450?
A
can lead to the generation of highly carcinogenic compounds
4
Q
How can drugs affect cytochrome P-450?
A
can act as
- substrates = are metabolised by cytochrome P-450
- inducers = increase the activity of cytochrome P-450
- inhibitors = decrease the activity of cytochrome P-450
5
Q
What are prodrugs?
A
are precursors the the drugs
- must be metabolised in the body