Cystic fibrosis and mucociliary escalator malfunction

Question 1

defect in the ENaC in CF in airway compared to epithelial layer?

Answer 1

CFTR is located on the basal surface of the cells lining the airways and GI glands and on the apical surface in the sweat ducts.

Question 2

CF clinical presentation

Answer 2

baby, child,

wheezing
salty skin
rhonchi on auscultation