Cyotoxic drugs

Question 1

Fluorouracil, MTX and anthracyclines are likely to result in what oral side effect?

Answer 1

Mucositis

Question 2

How is mucositis treated

Answer 2

• Good oral hygiene
• Sucking ice cubes
• saline mouth washes

Question 3

Patients with NHL, burkits lymphoma, ALL, AML are at high risk of what syndrome?

Answer 3

Tumour lysis syndrome

Question 4

A cancer patient presents with high urea, K+ and phosphate and low calcium - what could this be?

Answer 4

tumour lysis syndrome

Question 5

What medication is started to combate hyperureacemia

Answer 5

Allopurinol

Question 6

What 2 chemotherapies do NOT cause Bone marrow supression?

Answer 6

Bleomycin and vincristine

Question 7

What medication can be used to help with neutropenia

Answer 7

recombinant human granulocyte colony stimulating facotr

Question 8

What is the emetogenic risk of flurouracil, MTX, etoposide, vinca alkaloids?

Answer 8

mildly emetogenic

Question 9

What is the emetogenic risk of taxanes, doxorubicin, cyclophosphomide?

Answer 9

moderate

Question 10

What chemotherapy is highly emetogenic?

Answer 10

Cicplatin, dacarbazine, high dose ciclophosphamide

Question 11

What is the antidocte to MTX overdose

Answer 11

Folinic acid

Question 12

Urothelial toxicity is common with which chemotherapy drug?

Answer 12

Cyclophosphamide / ifosfomide

Question 13

What drug is given to help with symptoms of urothelial toxicity?

Answer 13

mesna

Question 14

Example of anthracycline drugs

Answer 14

Doxorubicin, Daunorubicin, epirubicin

Question 15

What is a dose limiting toxicity associated with anti-tumour antibiotics?

Answer 15

Cumulative cardiotoxicity - due to generation of free radicals. ECHO required pre treatment

Question 16

How must the Vinka alkaloids NOT be given?

Answer 16

intrathecally - risk of neurotoxicity

Question 17

Example of vinka alkaloid

Answer 17

Vinblastine, Vincristine

Question 18

Main risk with vinka alkaloids

Answer 18

Neurotoxicity

Question 19

Examples of Taxanes

Answer 19

Docetaxel, Paclitaxel

Question 20

examples of alkylating agents

Answer 20

cyclophosphamide, melphalan, ifosfamide, carmustine, chlorambucil

Question 21

Hand foot syndrome is associated with which antimetabolite drug?

Answer 21

fluorouracil + MTX

Question 22

Capecitabine is the oral equivalent of whay chemotherpay drug?

Answer 22

fluorouracil

Question 23

Pulmonary fibrosis is associated with which chemotherapy?

Answer 23

Bleomycin

Question 24

Monitoring for MTX

Answer 24

FBC, LFTS, U&Es every 1-2 weeks until stabilised, then 2/3 monthly
sx of pulmonary/blood toxicity

Question 25

Can NSAIDS be used wiht MTC?

Answer 25

No

Question 26

What does Dexrazoxane chelate?

Answer 26

Iron - used to prevent cumulative cardiotoxicity with anthracyclines

Question 27

When is Rasburicase contraindicated?

Answer 27

G6PD deficiency

Question 28

Bicalutamide is an anti androgen used in what form of cancer?

Answer 28

prostate

Question 29

How long can tamoxifen be used as chemoprevention?

Answer 29

5 years

Question 30

Aromatase inhibitor examples

Answer 30

Letrozole + anastrozole

Question 31

Erlotinib is an EGFR inhibitor. What is the MHRA warning associated with these medications?

Answer 31

Risk of keratitis and ulcerative keratitis