Cycloplegic refraction lecture Flashcards
What is min. pre-installation workup?
Hx, VA, Pupils, Slit lamp, Van Herick angles, Tonometry
Color of Cap indicates
Clear = anesthetic (Proparacaine/Altacaine) red = mydriatic/cycloplegic (Tropicamide,phenylephrine,cyclo) green = miotic
Why punctal occlude?
Prevent system absorption
Vasovagal syncope
transient, temporary loss of consciousness and posture
Action: keep pt safe, lower head and raise feet, open alcohol pad to smell, allow pt to rest 15-30 min
“if face is red, raise head. if face is pale, raise tail (feet)”
Standard Dilation drops?
1 drop 0.5% proparacaine/altacaine
1 drop 1% tropicamide
1 drop 2.5% phenylephrine
Anesthetics
prevents generation and conduction of nerve impulses by binding to specific receptors that control gating of Na channels
Anesthetic classification
Esters: cocaine, proparacaine, tetracaine, benzocaine
Amides: lidocaine and bupivacaine
Topical Anesthetics (Use, Side effects/adverse effects, Contraindications,)
Proparacaine or tetracaine
1 gtt 0.5% sol.
Duration: 10-20 min
USE: prevents sting, dec. blink rate & tearing, inc. drug penetration
Side effects: burning/stinging/lacrimation, punctate keratitis, corneal edema, conj. hyperemia, delayed corneal healing, blurred vision, tear film instability (dec. tbut, dec. mucous adherence), dec. reflex tearing, epithelial toxicity (sloughing inc.), endothelial toxicity, microbial contamination
2nd adverse effects:
hypofluorescence of fluorescein, variability in schirmer test, reduction of microbial recovery in culturing, surface keratopathy
contraindication: hypersensitivity
Cycloplegia Vs. Mydriasis
Cycloplegia: paralysis of ciliary muscle by anti-muscarinics
Mydriasis: dilation of pupil through dilator contraction by adrenergic agonists OR sphincter relaction by muscarinic antagonists.
Iris dilator and Iris sphincter
Iris dilator: sympathetic imput - pupil dilates when contracted (mydriasis)
Iris sphincter - parasympathetic input - cholinergic muscarinic (mydriasis and cycloplegia)
Mydriatics dilation (phenylephrine)
Stimulate adrenergic division of ans (bind and activcate alpha receptors)
sympathomimetics: increase pupil size - contracts iris dilator, widen palpebral fissure, constriction of blood vessels ‘blanching’, spares accommodation
Cycloplegia dilation (tropicamide)
inhibit cholinergic division of ans (block muscarinic receptors on ciliary muscle and prevent acetylcholine)
parasympatholytics: inhibit accommodation - ciliary muscle paralysis
Mydriatics indications
occurs within minutes and lasts 4-6 hours
indications: floaters, flashing lights, dec. va, unexplained vf, unknown etiology ocular pain, post trauma to eye, hx diabete, hx ret. disease, pupil defect or miosis, media opacities
mydriatic effects - age
older patients have release of pigment granules from iris neuro-epithelium after phenyelphrine
elderly - less mydriasis with phenyl and hydroxyamphetamine is less effective
Alpha agonists
visine and clear eyes
- causes rebound hyperemia and inc. conj injection
- conj. blanching “get the red out”
- more drug is required for same effect
- use caution in pt: taking inhibitors, tricyclic antidepressants, antihypertensive medications
phenylephrine (2.5%)
direct-acting alpha-adrenergic agonist - dilation and conj. vasoconstriction/blanching hyperemia -spares accommodation -pupil will constrict bright light max dilation = 45-60 min duration of dilation = 4-6 hrs
phenyl precautions, contraindications, side effects
systemic htn; dm1; heart disease; adv arteriosclerosis
contraindications: narrow angles, hypersensitivity, iris IOL, or pt taking MAO inhibitors, tricyclic antidepressants, reserpine, guanidine, methyldopa
side effects: ocular - lacrimation, keratitis, pigmented aqueous floaters, rebound miosis, rebound conj. congestion
systemic - systemic htn, occipital h/a, subarachnoid hemorrhage, ventricular arrhythmia, tachycardia, reflex bradycardia, blanching of skin - due to vasoconstriction
Type of Cycloplegia drugs
- Atropine (longest recovery mydriasis and cycloplegia)
- Scopolamine
- homatropine
- cyclopentolate
- tropicamide (shortest recovery mydriasis 6hrs and cycloplegia 6hrs)