Cycle du citrate Flashcards

1
Q

Généralités:
°Type
°Où se passe-t-il
°Bilan

A

°Catabolique oxidative
°Mitochondrie
°Pour un acétyl coA = 3 NADH, 1FADH2 et 1 GTP

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2
Q

Transformation du pyruvate:
°Enzyme
°Régulation

A

°Pyruvate en acétyl coa par la PDH
°PDH kinase inactive (+: ATP et NADH, -: Pyruvate)
°PDH phosphatase active (+: insuline)

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3
Q

3 réactions si on perd oxaloacétate

A

°Pyruvate en oaa (pyruvate carboxylase)
°PEP en oaa (PEP carboxykinase)
°Pyruvate en malate puis en oaa (voie mineur foie)

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4
Q

Réaction #1:
°Enzyme
°Autre chose?
°Réversible?

A

Aétyl coa+oaa en citrate
°Citrate synthase
°bye bye coa.sh
°Non

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5
Q

Réaction #2:
°Enzyme
°Autre chose?
°Réversible?

A

Citrate en isocitrate
°Aconitase
°Non
°Oui

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6
Q

Réaction #3:
°Enzyme
°Autre chose?
°Réversible?

A

Isocitrate en a-cétoglutarate
°isocitrate déshydrogénase
°NAD en NADH et perte d’un carbone
°Non

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7
Q

Réaction #4:
°Enzyme
°Autre chose?
°Réversible?

A

a-cétoglutarate en succinyl-coa
°a-cétoglutarate déshydrogénase
° ajout coa.sh et NAD en NADH
°Non

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8
Q

Réaction #5:
°Enzyme
°Autre chose?
°Réversible?

A

Succinly coa en succinate
°Succinate thiokinase
°Perte coa.sh et GDP en GTP
°oui

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9
Q

Réaction #6:
°Enzyme
°Autre chose?
°Réversible?

A

Succinate en fumarate
°succinate déshydrogénase
°FAD en FADH2
°oui

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10
Q

Réaction #7:
°Enzyme
°Autre chose?
°Réversible?

A

fumarate en malate
°fumarase
°non
°oui

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11
Q

Réaction #8
°Enzyme
°Autre chose?
°Réversible?

A

malate en oaa
°malate déshydrogénase
°NAD en NADH

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12
Q

3 enzymes régulés

A

°Citrate synthase
°Isocitrate déshydrogénase
°a-cétoglutarate déshydrogénase

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13
Q

Citrate synthase (3-)

A

°-: ATP, NADH, succinyl coa

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14
Q

a-cétoglutarate déshydrogénase (1+, 2-)

A

°+: AMP
°-: succinyl coa et NADH

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15
Q

Isocitrate déshydrogénase (2+, 1-)

A

°+: NAD, ADP
°-: ATP

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