Beta-oxidation Flashcards

1
Q

Généralités:
°Où
°Organes
°Régulation

A

°Mitochondrie (cytosol activation AG)
°Foie et muscles
°Insuline= (-), Adrénaline= (+)

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2
Q

Activation AG:
°Réaction
°Coût

A

°AG en acyl-coa
°1 ATP

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3
Q

Transport mitochondriale
°Régulation

A

check ton schéma
°Malonyl coa inhibe carnitine acyl transférase I

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4
Q

Réaction 1
°Enzyme
°Autre chose?

A

Acyl-coa en trans-∆2-enoyl-coa
°acyl-coa deshydrogénase
°FAD en FADH2

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5
Q

Réaction 2
°Enzyme
°Autre chose?

A

trans-∆2-enoyl-coa en beta-hydroxyacyl-coa
°enoyl-coa hydratase
°non

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6
Q

Réaction 3
°Enzyme
°Autre chose?

A

beta-hydroxyacyl-coa en beta-cétoacyl-coa
°3-hydroxyacyl-coa déshydrogénase
°NAD en NADH

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7
Q

Réaction 4
°Enzyme
°Autre chose?

A

beta-cétoacyl-coa en acétyl coa (cycle du citrate) + acyl coa
°beta-cétoacylthiolase
°non

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8
Q

Bilan: pour 16C

A

°8 acétyl coa
°7 NADH
°7 FADH2

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9
Q

Quoi faire si nb impair carbone (moins 1 ATP première réaction)

A

°Propionyl coa en D-méthyl-malonylcoa (propionyl coa carboxylase)
°D-méthyl-malonylcoa en L-méthyl-malonylcoa (épimérase)
°L-méthyl-malonylcoa en succinyl-coa (mutase)

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10
Q

Quoi faire si monoinsaturé

A

°Enzyme 3,2-enoyl-coa-isomérase à la place 1ère réaction
°Moins 1 FADH2

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