Cyanide poisoning Flashcards
What happens when there are large doses of cyanide?
The body’s ability to change cyanide into thiocyanate is overwhelmed.
What do large doses of cyanide prevent
It prevents cells from using oxygen in the electron transport chain eventually causing cell death.
Which parts of your body are more susceptible to cyanide poisoning?
The heart, respiratory system and central nervous system
What is another name for the Kreb’s cycle
The Cigtric Acid cycle (TCA)
What role does the Kreb’s cycle play
plays a central role in the breakdown, or catabolism, of organic fuel molecules.
The kreb’s cycle is made up of numerous steps catalyzed by
different enzymes that produce
energy at several different stages
The mitochondria play a central role in apoptosis. What is apoptosis?
silent cell death.
What causes apoptosis
An increase in mitochondrial membrane
permeability. This causes the release of mitochondrial enzymes.
Cytochrome C is an important factor in the electron transport chain. This activates an enzyme in the cytoplasm. What is the enzyme called?
The apoptosis activating factor
Which organelle is the only one that has its own DNA and what is that DNA
Mitochondria.
The DNA is mtDNA
define mitochondrial diseases
A group of disorders caused by dysfunctional mitochondria
The mitochondria are found in every cell of the human body except
red blood cells
Typically mitochondria diseases are caused by a
mutation in the mitochondrial DNA
Why do mitochondrial diseases often present with muscle weakness
and neuropathies?
These tissues present with the highest energy demands and any condition altering ATP production will cause them not to function
properly.
