CVS regulatory mechanisms Flashcards
What is the relationship between metabolic rate and blood flow?
Linear
How can blood flow by increased locally?
Autoregulation via myogenic responses
Locally produced vasodilator metabolites
How can blood flow by controlled systemically?
Nerves to control arteriole or circulating vasoactive substances
(short term)
In the long term there are changes to the size and number of blood vessels in the tissue
What are the local factors that cause a blood vessel to constrict?
Drop in temperature
Injured vessels
Autoregulation (myogenic response)
What are the local factors that cause a blood vessel to dilate?
Increased temp Hypoxia Increased pCO2 Lactate Cells leaking K+ Breakdown of ATP Histamine (adenosine is a vasodilator in cardiac muscle but not skeletal)
What are the endothelial products that cause constriction of blood vessels?
Endothelin-1
Locally released platelet serotonin
Thromboxane A2
What are the endothelial products that cause dilation of blood vessels?
Nitrous oxide
Kinins
Prostacylin
Which circulating hormones cause constriction of blood vessels?
Adrenaline (except in skeletal muscle and liver) Noradrenaline Angiotensin 2 Circulating Na/K ATPase inhibitor AVP Neuropeptide
Which circulating hormones cause dilation of blood vessels?
Adrenaline in skeletal muscle and liver CCRP-alpha Substance P Histamine ANP VIP
What are the neural factors which increase constriction of blood vessels?
Increased discharge of noradrenergic vasomotor nerves
What are the neural factors which increase dilation of blood vessels?
Decreased discharge of noradrenergic vasomotor nerves
Activation of cholinergic dilator fibres to skeletal muscle
How do additional blood vessels grow into tissue?
Endothelial cell growth factors
Fibroblast growth factor
Angiogenin
Where is prostacyclin produced?
Produced by endothelial and smooth muscle cells in blood vessels
What does prostacyclin do?
Inhibits platelet aggregation and promotes vasodilation ->increasing blood flow
Increases renin secretion by acting on juxtaglomerular cells
What makes thromboxane A2?
Made in platelets
Comes from common precursor arachnidonic acid via COX pathway
Promotes platelet aggregation and vasoconstriction
What is the action of aspirin?
Irreversible inhibition of cylooxygenase, shifts the balance more towards prostacyclin and causes bleeding
What is another name for nitric oxide?
Endothelium derived relaxing factor
What makes nitric oxide?
Made from arginine
Crosses cell membrane readily
What increases/decreases production of nitric oxide?
+ by products of platelet aggregation
- by Hb
What are the key functions of nitric oxide?
Vasodilation
Tonic release of NO is necessary to maintain BP
Helps penile erection
Vascular remodelling and angiogenesis
Important for brain function
Important for cytotoxic ability to kill cancer cells
What increases production of endothelin-1?
Stretched wall Hypoxia Ang II Catecholamines GF Insulin LDL, HDL Thrombin
What decreases the production of endothelin-1?
Nitric oxide
ANP
PGE2
Prostacylin